Wei et al., Mol Cell Biol 2003
:
Increased expression of p27 ( Kip1 ) increases the level of Sp1 promoter binding to the GC box but does not change the level of Sp3 binding ... p27 ( Kip1 ) leads to increased Sp1 binding through a decrease in Sp1 protein turnover
Lee et al., Biochem Pharmacol 2003
:
Involvement of PKA and Sp1 in the induction of p27 ( Kip1 ) by tamoxifen
Vivar et al., Biochem Pharmacol 2009
(Prostatic Neoplasms) :
Promoter deletion studies with p27 ( Kip1 ) reporter gene constructs showed that this DIM mediated increase in p27 ( Kip1 ) was dependent on the Sp1 transcription factor Zhang et al., Biochim Biophys Acta 1997
:
Taken together, our data strongly show that the p27 promoter is activated by the ubiquitously expressed transcription factor Sp1 , which may provide a molecular mechanism for the constitutive nature of p27 transcription