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FOXP3 — MSC
Text-mined interactions from Literome
English et al., Clin Exp Immunol 2009
:
This phenomenon required direct contact between MSC and purified T cells, although cell contact was not required for
MSC induction of
FoxP3 expression in an unseparated mononuclear cell population
Sundin et al., J Immunother 2009
(Graft vs Host Disease) :
Although
MSC up-regulated lymphocyte gene expression of CD25, IFN-gamma,
FoxP3 , CTLA-4, and IL-10, they failed in both unprimed and primed responders to induce CD25+ ( activated ) or CD57+ ( effector ) CD4+ or CD8+ T-lymphocyte subsets and only inconsistently induced FoxP3+ regulatory T-lymphocytes
Zhao et al., Eur J Cancer 2012
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
CML-MSC-DCs derived TGF-ß1 was largely
responsible for the increase in
CD4+CD25+Foxp3+Tregs based on knockdown studies
Zhao et al., PloS one 2012
(Myelodysplastic Syndromes) :
At last, we find that
MDS-MSC derived TGF-ß1 is largely
responsible for the increase in
CD4+CD25+Foxp3+Tregs based on knockdown studies