Gene interactions and pathways from curated databases and text-mining

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FOXP3 — MSC

Text-mined interactions from Literome

English et al., Clin Exp Immunol 2009 : This phenomenon required direct contact between MSC and purified T cells, although cell contact was not required for MSC induction of FoxP3 expression in an unseparated mononuclear cell population
Sundin et al., J Immunother 2009 (Graft vs Host Disease) : Although MSC up-regulated lymphocyte gene expression of CD25, IFN-gamma, FoxP3 , CTLA-4, and IL-10, they failed in both unprimed and primed responders to induce CD25+ ( activated ) or CD57+ ( effector ) CD4+ or CD8+ T-lymphocyte subsets and only inconsistently induced FoxP3+ regulatory T-lymphocytes
Zhao et al., Eur J Cancer 2012 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : CML-MSC-DCs derived TGF-ß1 was largely responsible for the increase in CD4+CD25+Foxp3+Tregs based on knockdown studies
Zhao et al., PloS one 2012 (Myelodysplastic Syndromes) : At last, we find that MDS-MSC derived TGF-ß1 is largely responsible for the increase in CD4+CD25+Foxp3+Tregs based on knockdown studies