◀ Back to ADCY2

ADCY2 — WAS

Text-mined interactions from Literome

Hillard et al., Biochem Pharmacol 1986 : 11-OH-delta 9-THC , a psychoactive metabolite of delta 9-THC, also increased glucagon activation of adenylate cyclase while two cannabinoids without marihuana-like psychoactive potency, cannabinol and cannabidiol, did not ... Therefore, delta 9-THC increased the coupling of the glucagon receptor to adenylate cyclase apparently by removing a constraint on receptor-Ns coupling
Howlett et al., Neuropharmacology 1987 : delta 9Tetrahydrocannabinol (THC) has been shown to inhibit the activity of adenylate cyclase in the N18TG2 clone of murine neuroblastoma cells
Li et al., Clin Exp Pharmacol Physiol 1984 : delta 1-THC 25, 50 and 100 micrograms significantly reduced the adenylate cyclase activity with the maximum effect observed with the dose of 25 micrograms
Fride et al., J Pharmacol Exp Ther 1995 : Thus a significant decrease in the potency of delta 9-THC induced inhibition of adenylate cyclase was observed in N18TG2 neuroblastoma cells that were pretreated with low concentrations of anandamides
Kaminski et al., Biochem Pharmacol 1994 : These findings, together with those demonstrating that delta 9-THC inhibits adenylate cyclase in splenocytes, strongly suggest that certain aspects of immune inhibition by cannabinoids may be mediated through a cannabinoid receptor associated mechanism