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FGF2 — PLD2

Text-mined interactions from Literome

Sa et al., Mol Cell Biochem 1999 : Basic fibroblast growth factor stimulates cytosolic phospholipase A2, phospholipase C-gamma1 and phospholipase D through distinguishable signaling mechanisms ... Upon binding to FGFR1, basic FGF stimulates cytosolic form of phospholipase A2 ( cPLA2 ), phospholipase C-gamma1 ( PLC-gamma1 ) and phospholipase D ( PLD ) , the key enzymes for the production of various lipid second messengers, in a tyrosine kinase dependent manner
Oh et al., J Cell Biochem 2007 (Cell Transformation, Viral) : Transfection of DN-rPLD1 blocked bFGF induced PLD activation and completely inhibited neurite outgrowth induced by bFGF, suggesting that PLD1 activation is important in bFGF induced neurite outgrowth of H19-7 cells ... PLD activation and neurite outgrowth induced by bFGF was dependent on phospholipase C gamma (PLC-gamma) and Ca2+, but not protein kinase C ( PKC ) ... Furthermore, inhibition of Src and Ras partially blocked bFGF induced PLD activation and neurite outgrowth, respectively ... Coinhibition of Src and Ras completely blocked bFGF induced PLD activation , suggesting that Src and Ras independently regulate PLD1 activation ... Interestingly, bFGF induced PLD activation and neurite outgrowth did not require ERK1/2 activated by Ras
Yoon et al., Biochem J 2012 : We found that Ras was the most upstream molecule among these proteins, followed by the PI3K/PLC? pathway, indicating that bFGF induced PLD activation took place through the Ras/PI3K/PLC? pathway
Morrison et al., J Cell Physiol 1995 : Neither basic Fibroblast Growth Factor (bFGF) or Epidermal Growth Factor (EGF) increased PLD activity
Yeo et al., J Biol Chem 1995 : EGF, basic fibroblast growth factor (bFGF) , bombesin, and platelet derived growth factor ( PDGF ) activated PLD as measured by transphosphatidylation of butanol to phosphatidylbutanol
Ahmed et al., Am J Physiol 1994 : The ability of bFGF and 12-O-tetradecanoylphorbol-13-acetate ( TPA ) to stimulate PLD activity was completely abolished in cells pretreated with 400 nM TPA for 48 h to downregulate protein kinase C ( PKC ) ... bFGF stimulated PLD activity was inhibited by genistein ( 5 microM ; P < 0.02 ) and the PKC inhibitor 1- ( 5-isoquinolinylsulfonyl ) -2-methylpiperazine ( H-7, 5 microM ; P < 0.001 ) as well as by the removal of calcium from extracellular environment ... These results indicate that activation of PKC is responsible for bFGF induced PLD activation and the mitogenic activity of bFGF in HUVE cells
Hou et al., Cell Signal 1996 : Wortmannin, an inhibitor of basic fibroblast growth factor stimulated phospholipase D , did not affect arachidonic acid release
van Dijk et al., Biochim Biophys Acta 1998 : Downregulation of protein kinase C blocked bFGF induced PLD activation but not phosphatidic acid formation by diacylglycerol ( DG ) kinase