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EGFR — ERBB3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of EGFR-ERBB3 → BTC (directlyIncreases)
  Evidence: the second group betacellulin (BTC), heparin-binding EGF (HB-EGF), and epiregulin (EPR), which exhibit dual specificity in that they bind ErbB1 and ErbB4.
• OpenBEL Selventa BEL large corpus: ERBB3 → EGFR (decreases)
  Evidence: The level of erbB-2 expression was nearly identical in both control and EGFR anti-sense gene-transfected cells (Fig. 5b), while the level of erbB-3 protein expression was 40% higher in EGFR anti-sense vector-transfected cells (Fig. 5c).
• OpenBEL Selventa BEL large corpus: ERBB3 → EGFR (directlyIncreases, EGFR Activity, ERBB3 Activity)
  Evidence: Mutant EGFR phosphorylates the kinase-impaired receptor HER3 (also known as Erb3), which then potently activates the phosphatidylinositol-3 kinase (PI3K) and Akt cell survival pathways
• OpenBEL Selventa BEL large corpus: ERBB3 → EGFR (directlyIncreases, ERBB3 Activity)
  Evidence: Mutant EGFR phosphorylates the kinase-impaired receptor HER3 (also known as Erb3), which then potently activates the phosphatidylinositol-3 kinase (PI3K) and Akt cell survival pathways
• BioCarta role of erbb2 in signal transduction and oncology: ERBB2/ERBB 1/3/4 complex (ERBB2-ERBB4_ERBB3_EGFR) → ERBB ligand/ERBB2/ERBB 1/3/4 complex (ERBB2-ERBB4_ERBB3_EGFR) (modification, collaborate)
  
• NCI Pathway Database ErbB receptor signaling network: EGFR (EGFR) → ErbB3 (ERBB3) (modification, collaborate) Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGFR (EGFR) → EGFR/ErbB3/amphiregulin complex (EGFR-ERBB3-AREGB) (modification, collaborate)
  Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: amphiregulin (AREGB) → EGFR/ErbB3/amphiregulin complex (EGFR-ERBB3-AREGB) (modification, collaborate)
  Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: ErbB3 (ERBB3) → EGFR/ErbB3/amphiregulin complex (EGFR-ERBB3-AREGB) (modification, collaborate)
  Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGF (EGF) → EGFR/ErbB3/EGF complex (EGFR-ERBB3-EGF) (modification, collaborate)
  Marqués et al., Exp Cell Res 1999*, Soltoff et al., Mol Cell Biol 1994*, Kim et al., J Biol Chem 1994*, Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGFR (EGFR) → ErbB3 (ERBB3) (modification, collaborate) Marqués et al., Exp Cell Res 1999*, Soltoff et al., Mol Cell Biol 1994*, Kim et al., J Biol Chem 1994*, Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGFR (EGFR) → EGFR/ErbB3/EGF complex (EGFR-ERBB3-EGF) (modification, collaborate)
  Marqués et al., Exp Cell Res 1999*, Soltoff et al., Mol Cell Biol 1994*, Kim et al., J Biol Chem 1994*, Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: ErbB3 (ERBB3) → EGFR/ErbB3/EGF complex (EGFR-ERBB3-EGF) (modification, collaborate)
  Marqués et al., Exp Cell Res 1999*, Soltoff et al., Mol Cell Biol 1994*, Kim et al., J Biol Chem 1994*, Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGFR/ErbB3/TGFA complex (EGFR-ERBB3-TGFA) → EGFR (EGFR) (modification, collaborate) Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGFR/ErbB3/TGFA complex (EGFR-ERBB3-TGFA) → ErbB3 (ERBB3) (modification, collaborate) Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGFR/ErbB3/TGFA complex (EGFR-ERBB3-TGFA) → TGFA (TGFA) (modification, collaborate) Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGFR (EGFR) → ErbB3 (ERBB3) (modification, collaborate) Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGFR/ErbB3/epiregulin complex (EGFR-ERBB3-EREG) → EGFR (EGFR) (modification, collaborate) Komurasaki et al., Oncogene 1997
  Evidence: physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGFR/ErbB3/epiregulin complex (EGFR-ERBB3-EREG) → ErbB3 (ERBB3) (modification, collaborate) Komurasaki et al., Oncogene 1997
  Evidence: physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGFR/ErbB3/epiregulin complex (EGFR-ERBB3-EREG) → epiregulin (EREG) (modification, collaborate) Komurasaki et al., Oncogene 1997
  Evidence: physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGFR (EGFR) → ErbB3 (ERBB3) (modification, collaborate) Komurasaki et al., Oncogene 1997
  Evidence: physical interaction
• Reactome Reaction: EGFR → ERBB3 (reaction) Vijapurkar et al., Exp Cell Res 2003, Walton et al., J Biol Chem 1990, Li et al., Cell Signal 2007, Xu et al., Mol Cell Biol 2007, Hazan et al., Cell Growth Differ 1990, Kaushansky et al., Chem Biol 2008, Helin et al., J Biol Chem 1991, Margolis et al., J Biol Chem 1989, Ricci et al., Oncogene 1995, Wallasch et al., EMBO J 1995, Prigent et al., EMBO J 1994, Soler et al., Oncogene 1994, Segatto et al., Oncogene 1993, Cohen et al., J Biol Chem 1996, Pinkas-Kramarski et al., EMBO J 1996

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: EGFR — ERBB3 (physical association, affinity chromatography technology) Marqués et al., Exp Cell Res 1999*
• IRef Hprd Interaction: ERBB3 — EGFR (in vivo) Marqués et al., Exp Cell Res 1999*
• IRef Intact Interaction: Complex of ROR1-EGFR-ERBB3-EGFR-ERBB3-ROR1-ROR1-EGFR-ERBB3 (association, anti bait coimmunoprecipitation) Yamaguchi et al., Cancer Cell 2012*
• IRef Intact Interaction: Complex of 29 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 40 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of UBASH3B-CDC37-EGFR-ERBB3-ERRFI1-SHC1-ERBB2-STAT3 (association, anti bait coimmunoprecipitation) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: ERBB3 — EGFR (physical association, anti bait coimmunoprecipitation) Fernandes et al., Am J Respir Cell Mol Biol 1999*
• IRef Intact Interaction: ERBB3 — EGFR (physical association, protein cross-linking with a bifunctional reagent) Serra et al., Oncogene 2011*
• IRef Intact Interaction: Complex of PIK3R1-SHC1-ERBB2-ERBB3-EGFR (association, pull down) Wang et al., Cancer Cell 2006
• IRef Ophid Interaction: ERBB3 — EGFR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Lin et al., Cancer Res 1999 (Prostatic Neoplasms) : In response to ErbB1 activation by ligand, the p85 regulatory subunit of PI3K associated specifically with ErbB3 but not detectably with ErbB1
Contessa et al., Oncogene 2002 (Breast Neoplasms...) : EGFR dependent Erb-B3 signaling also contributed to p70 S6 kinase activity through recruitment and activation of PI3K, which has been shown to regulate p70 S6 kinase activity
Kinugasa et al., Biochem Biophys Res Commun 2004 : A newly established anti-ErbB3 neutralizing monoclonal antibody ( # 5C3 ) almost completely blocked NGC induced ErbB activation in MDA-MB-453 cells
Ratchford et al., J Biol Chem 2010 : Furthermore, stimulation of HSG cells with UTP induced phosphorylation of ErbB3 , and silencing of ErbB3 expression inhibited UTP induced phosphorylation of both ErbB3 and EGFR
Schoeberl et al., Cancer Res 2010 (Neoplasms) : We found that MM-121 effectively blocked ligand dependent activation of ErbB3 induced by either EGFR , HER2, or MET
Hsieh et al., Hepatology 2011 (Carcinoma, Hepatocellular...) : Human epidermal growth factor receptor 2 was required for ERBB3 phosphorylation
Bruzzese et al., J Cell Physiol 2011 (Carcinoma, Squamous Cell...) : Attenuation of all ErbB transcripts in CAL27 cells as well as induction of ErbB3 transcript in Hep-2 and KB cells was seen upon vorinostat treatment
Grøvdal et al., Cell Signal 2012 (Breast Neoplasms) : ErbB3 expression was upregulated not only by gefitinib but also by a panel of different EGFR inhibitors, suggesting that inhibition of EGFR in general affects ErbB3 expression