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HIF1A — PDC

Text-mined interactions from Literome

Metzen et al., J Cell Sci 2003 (Osteosarcoma) : In contrast to FIH-1, each PHD inhibited nuclear HIF-1 alpha accumulation in hypoxia
Asikainen et al., Proc Natl Acad Sci U S A 2005 (Hyperoxia) : PHD inhibitor ( FG-4095 ) and positive control dimethyloxaloylglycine ( DMOG ), selective and nonselective HIF-PHD inhibitors, respectively, enhanced HIF-1alpha and -2alpha, vascular endothelial growth factor ( VEGF ), and platelet-endothelial cell adhesion molecule 1 expression in vitro in 95 % and 21 % O2
Li et al., American journal of physiology. Renal physiology 2007 (Anoxia) : Because HIF-1alpha is highly expressed in the renal medulla and HIF-1alpha targeted genes such as nitric oxide synthase, cyclooxygenase, and heme oxygenase are important in the regulation of renal medullary function, we hypothesized that PHD regulates HIF-1alpha levels in the renal medulla and, thereby, participates in the control of renal Na ( + ) excretion
Yin et al., J Biol Chem 2007 (Anoxia...) : Our results further demonstrate that MUC1 blocks hypoxia induced increases in ROS and thereby potentiates PHD mediated HIF-1alpha suppression
Imaoka et al., Biochem Biophys Res Commun 2007 (Eye Abnormalities) : xHIF-1alpha protein level was at a maximum around stage 20 when expression of PHD45 disappeared, while expression of PHD28 reached a maximum at stage 20, suggesting that PHD28 is inducible by HIF-1alpha
Floyd et al., J Cell Biochem 2007 : However, inhibition of PHD activity does not consistently regulate HIF-1alpha l.1 expression or HIF-1alpha protein levels, suggesting that hydroxylation independent mechanisms are involved in regulating HIF-1alpha expression in adipocytes under aerobic conditions
Klein et al., Mol Biol Cell 2008 (Anoxia...) : Overexpression of HIF-1 alpha induced STK15 gene transcription, whereas HIF-1 alpha siRNA and overexpression of prolyl hydroxylase 2 (PHD-2) , a negative regulator of HIF-1 alpha , reversed this effect