◀ Back to MAPK7
MAPK7 — MEF2D
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
MEF2D
→
MAPK7
(directlyIncreases, MAPK7 Activity, MEF2D Activity)
Kato et al., J Biol Chem 2000*
Evidence: Here, we demonstrate that, in addition to MEF2C, BMK1 phosphorylates and activates MEF2A and MEF2D but not MEF2B. The blocking of BMK1 signaling inhibits the epidermal growth factor-dependent activation of these three MEF2 transcription factors. The sites phosphorylated by activated BMK1 were mapped to Ser-355, Thr-312, and Thr-319 of MEF2A and Ser-179 of MEF2D both in vitro and in vivo.
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BioCarta control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk):
ERK5 (MAPK7)
→
MEF2/MYOD complex (MYOD1-MEF2C_MEF2B_MEF2D_MEF2A)
(transcription, activates)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Biogrid Interaction:
MEF2D
—
MAPK7
(physical association, affinity chromatography technology)
Yang et al., Nucleic Acids Res 1998*
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IRef Biogrid Interaction:
MEF2D
—
MAPK7
(direct interaction, pull down)
Yang et al., Nucleic Acids Res 1998*
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IRef Biogrid Interaction:
MEF2D
—
MAPK7
(direct interaction, enzymatic study)
Yang et al., Nucleic Acids Res 1998*
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IRef Biogrid Interaction:
MEF2D
—
MAPK7
(direct interaction, two hybrid)
Yang et al., Nucleic Acids Res 1998*
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IRef Hprd Interaction:
MAPK7
—
MEF2D
(in vivo)
Kato et al., J Biol Chem 2000*, Yang et al., Nucleic Acids Res 1998*
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IRef Hprd Interaction:
MAPK7
—
MEF2D
(in vitro)
Kato et al., J Biol Chem 2000*, Yang et al., Nucleic Acids Res 1998*
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IRef Ophid Interaction:
MAPK7
—
MEF2D
(aggregation, confirmational text mining)
Yang et al., Nucleic Acids Res 1998*
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IRef Ophid Interaction:
MAPK7
—
MEF2D
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Kato et al., J Biol Chem 2000
:
Here, we demonstrate that, in addition to MEF2C,
BMK1 phosphorylates and
activates MEF2A and
MEF2D but not MEF2B
Zhao et al., Arch Biochem Biophys 2002
(Arteriosclerosis) :
The exclusive
activation of
MEF2D by
BMK1 appears required for this cooperative upregulation of c-jun in VSMC, and coactivation of p38 and BMK1 also has additive effects on the activation of a reporter gene linked to the c-jun promoter in our experimental system
Aziz et al., Epigenetics 2010
(MAP Kinase Signaling System) :
Modulation of the interaction between Ash2L/MLL2 and
Mef2d by the p38a
MAPK signaling pathway in turns provides fine tuning of the muscle-specific gene expression program