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LEP — SH2B1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
LEP
→
SH2B1
(reaction)
Nishi et al., Mol Cell Biol 2005, Li et al., Mol Endocrinol 2007
-
Reactome Reaction:
LEP
→
SH2B1
(indirect_complex)
Szanto et al., Proc Natl Acad Sci U S A 2000, Martín-Romero et al., Cell Immunol 2001, Duan et al., J Biol Chem 2004, Nishi et al., Mol Cell Biol 2005, Li et al., Mol Endocrinol 2007, Hill et al., J Clin Invest 2008, Buettner et al., Nat Med 2008, Bjørbaek et al., J Biol Chem 1997
Text-mined interactions from Literome
Li et al., Endocrinology 2006
(Body Weight...) :
SH2-B and APS, two members of a pleckstrin homology and SH2 domain containing adaptor family,
promote both insulin and
leptin signaling in a similar fashion in cultured cells
Li et al., Endocrinology 2007
:
In mice,
SH2B1 regulates energy and glucose homeostasis by enhancing
leptin and insulin sensitivity
Li et al., Mol Endocrinol 2007
:
SH2B1 enhances
leptin signaling by both Janus kinase 2 Tyr813 phosphorylation dependent and -independent mechanisms ...
Leptin promoted the interaction of
SH2B1 with IRS1 ...
Leptin stimulated
SH2B1-JAK2 interaction, mediated by the SH2 domain of SH2B1 and phospho-Tyr ( 813 ) in JAK2, promotes JAK2 activation, thus globally enhancing leptin signaling
Rider et al., Mol Endocrinol 2009
:
The Src homology 2 (SH2) domain containing adapter protein
SH2B1beta plays a role in severe obesity,
leptin and insulin resistance, and infertility