◀ Back to BCR
BCR — CD40
Text-mined interactions from Literome
Qi et al., Proc Natl Acad Sci U S A 2003
:
Rapid activation of CTCF by
BCR ligation or treatment with TGF-beta was
suppressed by ligation of
CD40
Hokazono et al., J Immunol 2003
:
Ag-induced B cell proliferation in vivo requires a costimulatory signal through CD40, whereas
B cell Ag receptor (BCR) ligation by anti-Ig H chain Abs, such as anti-Ig micro H chain Ab and anti-Ig delta H chain Ab, alone
induces proliferation of B cells in vitro, even in the absence of
CD40 ligation
Masilamani et al., Eur J Immunol 2003
:
CD21 shedding is induced by stimulation with PMA plus Ca ( 2+ ) ionophore, or by
stimulation of the
BCR with
anti-IgM+anti-CD40
Hillion et al., J Immunol 2007
:
In previous studies, we demonstrated that cross linking the
BCR and the
CD40 induces the expression of the RAG1 and RAG2 enzymes and, thereby, secondary rearrangements
Henry et al., J Immunol 2009
(Calcium Signaling) :
These include
BCR down-regulation, impaired proliferative
responses to
anti-CD40 , and diminished calcium mobilization upon stimulation with BCR dependent and independent stimuli
Man et al., PloS one 2010
:
Both
BCR signaling defect and augmented
response to
CD40 ligation are partially restored in xid IgG-transgenic mice in which BCR signaling is down modulated due to a loss-of-function mutation in the tyrosine kinase Btk crucial for BCR signaling
Ying et al., Immunobiology 2011
:
It has been shown that CD40 stimulation can augment BCR induced B cell responses, but the molecular mechanism ( s ) by which
CD40 regulates
BCR signaling is poorly understood
Mullins et al., Mol Immunol 1998
:
Finally,
CD40 mediated signals
induce resting B cells to accumulate the CKI, p21, while cycling B cells require both
BCR- and CD40 mediated signals to maintain increased expression of p21