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ARSA — CDKN1A

Text-mined interactions from Literome

Zhou et al., Cancer Lett 2009 (Necrosis...) : NO-ASA induced COX-2 expression starting 90 min after p21 ( cip-1 ) was induced
Hua et al., Int J Oncol 2009 (Colonic Neoplasms) : The principal differences between the two isomers were : a ) p-NO-ASA exerts its effect earlier than m-NO-ASA ; b ) the predominant effect of m-NO-ASA is on ERK1/2 and Akt ; whereas that of p-NO-ASA is on JNK1/2, while both activate p38, with p-NO-ASA showing a stronger and earlier effect ; c ) ATF-2 is more responsive to m-NO-ASA and c-Jun to p-NO-ASA ; d ) both isomers seem to have similar effects on AP-1 binding, the main difference between them being the timing of the effect ; p-NO-ASA 's effect is early and m-NO-ASA 's is late ; e ) p-NO-ASA has an earlier and stronger effect on p21, while m-NO-ASA 's effect occurs later and is weaker ; and f ) cell cycle changes follow the effect on p21 expression
Son et al., Cancer Biol Ther 2010 (Ovarian Neoplasms) : Furthermore, COX-1 siRNA attenuated the effects of combined ASA and FK228 on the levels of p21 expression and the amount of growth inhibition