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NOTCH3 — SMAD4

Text-mined interactions from Literome

Abe et al., Mech Dev 2005 : Notch signal activation restored the ability of C-terminal phosphorylated smad2 to bind to smad4 , resulting in a delay in the onset of LMC
Kennard et al., J Biol Chem 2008 : The repression of Notch3 was mediated by SMAD activity and p38 mitogen activated protein ( MAP ) kinase, whereas analysis of the Hes1 promoter revealed direct activation by Smad2 but not Smad3
Fu et al., J Biol Chem 2009 : This is the first evidence that Notch activation affects R-Smad expression and that cooperative induction of histone acetylation at specific promoters underlies the selective synergy between Notch and TGFbeta signaling pathways