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APC — CDC23
Text-mined interactions from Literome
Cheng et al., Mol Cell Biol 1999
:
We had previously shown that Dbf4p interacts with the M phase polo-like kinase
Cdc5p , a key
regulator of the
APC late in mitosis
Fang et al., Philos Trans R Soc Lond B Biol Sci 1999
:
Therefore,
CDC20 and CDH1
control both the temporal order of activation and the substrate specificity of
APC , and hence regulate different events during mitosis and G1
Shirayama et al., Nature 1999
:
Here we show that
APC ( Cdc20 )
allows activation of
Cdc14 and promotes exit from mitosis by mediating proteolysis of Pds1 and the S phase cyclin Clb5 in the yeast Saccharomyces cerevisiae
Rudner et al., J Cell Biol 2000
:
CDC28-VF has
reduced Cdc20- dependent
APC activity in mitosis, but normal Hct1- dependent APC activity in the G1 phase of the cell cycle
Rudner et al., J Cell Biol 2000
:
The mitotic activity of
Cdc28 ( Cdk1 ) is
required to activate this form of the
APC , and mutants that are impaired in mitotic Cdc28 function have difficulty leaving mitosis
Izawa et al., Nature 2005
:
Inhibition of
APC/C dependent degradation of
Cdc13p by Mes1p was reproduced in a Xenopus egg extract
Izawa et al., Nat Cell Biol 2011
:
Cdc20
requires APC3 and
APC8 to bind and activate the
APC/C when the SAC is satisfied, but requires only APC8 to bind the APC/C when the SAC is active
Charles et al., Curr Biol 1998
:
Overexpression of
CDC5 resulted in increased
APC activity and mitotic cyclin destruction in asynchronous cells or in cells arrested in metaphase
Jaspersen et al., Mol Biol Cell 1998
:
We conclude that
Cdc15 , Cdc5, Cdc14, Dbf2, and Tem1 cooperate in the
activation of the
APC in late mitosis but are not required for maintenance of that activity in G1