Gene interactions and pathways from curated databases and text-mining

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APC — CDC23

Text-mined interactions from Literome

Cheng et al., Mol Cell Biol 1999 : We had previously shown that Dbf4p interacts with the M phase polo-like kinase Cdc5p , a key regulator of the APC late in mitosis
Fang et al., Philos Trans R Soc Lond B Biol Sci 1999 : Therefore, CDC20 and CDH1 control both the temporal order of activation and the substrate specificity of APC , and hence regulate different events during mitosis and G1
Shirayama et al., Nature 1999 : Here we show that APC ( Cdc20 ) allows activation of Cdc14 and promotes exit from mitosis by mediating proteolysis of Pds1 and the S phase cyclin Clb5 in the yeast Saccharomyces cerevisiae
Rudner et al., J Cell Biol 2000 : CDC28-VF has reduced Cdc20- dependent APC activity in mitosis, but normal Hct1- dependent APC activity in the G1 phase of the cell cycle
Rudner et al., J Cell Biol 2000 : The mitotic activity of Cdc28 ( Cdk1 ) is required to activate this form of the APC , and mutants that are impaired in mitotic Cdc28 function have difficulty leaving mitosis
Izawa et al., Nature 2005 : Inhibition of APC/C dependent degradation of Cdc13p by Mes1p was reproduced in a Xenopus egg extract
Izawa et al., Nat Cell Biol 2011 : Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the SAC is satisfied, but requires only APC8 to bind the APC/C when the SAC is active
Charles et al., Curr Biol 1998 : Overexpression of CDC5 resulted in increased APC activity and mitotic cyclin destruction in asynchronous cells or in cells arrested in metaphase
Jaspersen et al., Mol Biol Cell 1998 : We conclude that Cdc15 , Cdc5, Cdc14, Dbf2, and Tem1 cooperate in the activation of the APC in late mitosis but are not required for maintenance of that activity in G1