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KLF11 — SMAD7

Text-mined interactions from Literome

Ellenrieder et al., Gastroenterology 2004 (Carcinoma, Pancreatic Ductal...) : Erk induced KLF11 phosphorylation was examined in vitro and in vivo, and its impact on KLF11-mSin3A mediated Smad7 repression was verified in pancreatic cancer cells using site directed mutagenesis ... Mechanistically, KLF11 represses TGF-beta induced transcription from the Smad7 promoter by recruiting mSin3a via GC-rich sites ... Expression of an Erk-insensitive KLF11 mutant restores both mSin3a binding and Smad7 repression and results in enhanced TGF-beta signaling in pancreatic cancer cells
Gutierrez-Aguilar et al., Diabetes Metab 2007 (Diabetes Mellitus, Type 2...) : The expression of SMAD7 is affected by KLF11 , which contains gene variants that have previously been shown to be involved in genetic susceptibility to T2D, and by the highly homologous KLF10