◀ Back to TNF
DDB2 — TNF
Text-mined interactions from Literome
Kim et al., Liver 2000
:
Effects of
DDB on the expression of xenobiotic metabolizing enzymes and on nuclear factor-kappaB (NF-kappaB) activation and
tumor necrosis factor-alpha (TNF-alpha) production by lipopolysaccharide (LPS), an endotoxin involved in inflammatory responses, were examined in rats and in RAW264.7 cells to investigate mechanistic aspects ... LPS induced I-kappaBalpha degradation and
TNF-alpha production were also
inhibited by
DDB in RAW264.7 cells, which was consistent with the results in rats
Sun et al., Int J Cancer 2005
(Xeroderma Pigmentosum) :
Moreover, overexpression of
DDB2 in HR18 cells also
attenuated TNF-alpha induced caspase activation
Gao et al., Liver Int 2005
(Disease Models, Animal...) :
These results suggest that
DDB could directly protect hepatocyte DNA from oxidative damage, and
inhibit TNF-alpha mRNA expression in liver tissue, which resulted in prevention of liver damage induced by Con A in mice