◀ Back to TNF

NPY4R — TNF

Text-mined interactions from Literome

Orlicek et al., Shock 1999 : The src family-selective tyrosine kinase inhibitor PP1 blocks LPS and IFN-gamma mediated TNF and iNOS production in murine macrophages ... We report that the pyrazolopyrimidine PP1 , a src family-selective tyrosine kinase inhibitor, potently inhibits the production of TNF and inducible nitric oxide synthase (iNOS) in RAW 264.7 murine macrophages stimulated with LPS, rlFN-gamma, or LPS + rIFN-gamma
Lin et al., J Immunol 2000 : OX8 ( CD8 alpha ) -induced TNF and IL-1 beta production by macrophages was blocked by inhibitors of protein tyrosine kinase ( s ), PP1 , and genistein, but not by phosphatidylinositol-3 kinase inhibitor, wortmannin
Redondo et al., Mol Cell Endocrinol 2003 : Wortmannin ( PI3K/PKB inhibitor ) blocked the stimulatory action of insulin on glycogen synthase a and reduced that of GLP-1 ; rapamycin ( p70s6k inhibitor ) was ineffective and PD98059 ( MEK/MAPK inhibitor ) decreased only the insulin effect ; okadaic acid ( PP-2A inhibitor ) was ineffective, while TNFalpha ( PP-1 inhibitor ) blocked the action of insulin and reduced that of GLP-1 ; H-7 or Ro 31-8220 ( PKC inhibitors ) decreased the GLP-1 effect, while only H-7 reduced that of insulin
Stovall et al., J Biol Chem 2004 : PP1 , a selective inhibitor of src related tyrosine kinases, blocked both the CpG DNA mediated tyrosine phosphorylation of vav1 and the CpG DNA mediated up-regulation of macrophage tumor necrosis factor secretion and inducible nitric-oxide synthase protein accumulation
Ghosh et al., Endocrinology 2007 (Insulin Resistance) : TNFalpha increased serine/threonine phosphatase activity of protein phosphatase 1 (PP1) in response to C6, but not insulin, suggesting a ceramide-specific effect
Lee et al., J Immunol 2007 (Respiratory Distress Syndrome, Adult) : PP1 inhibited LPS induced increases in total protein content in bronchoalveolar lavage fluid, neutrophil recruitment, and increases in the production or activity of TNF-alpha and matrix metalloproteinase-9
Nie et al., Nat Med 2013 (Arthritis, Rheumatoid) : In rheumatoid arthritis derived T cells, the Ser418 site was specifically dephosphorylated by protein phosphatase 1 (PP1) , whose expression and enzymatic activity were induced in the inflamed synovium by tumor necrosis factor a (TNF-a) , leading to impaired T cell function
Begum et al., Endocrinology 1996 : In this study, the acute effects of tumor necrosis factor (TNF)-alpha on insulin stimulated glucose uptake, glycogen synthesis, and protein phosphatase-1 (PP-1) activation were examined in cultured rat skeletal muscle cell line, L6 ... Because GS is activated by dephosphorylation via protein phosphatase-1 (PP-1), we examined the effect of TNF- alpha on PP-1 activation ... cAMP-Rp diastereomer, a cAMP antagonist failed to prevent the detrimental effects of TNF-alpha on PP-1 ... Cell permeable ceramide analogs, C2, C6, and Sphingomyelinase mimicked the effects of TNF-alpha on PP-1 inhibition
Begum et al., Eur J Biochem 1996 : Therefore, we examined the effect of TNF-alpha on protein phosphatase-1 (PP-1) and protein phosphatase-2A (PP-2A) activities