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ID1 — SMAD3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Korchynskyi et al., J Biol Chem 2002
:
BMP, but not TGF-beta, strongly activates the
Id1 promoter in an
Smad dependent manner
Kashiwakura et al., Cancer Res 2008
(Multiple Myeloma) :
Mutagenesis experiments with the 2.1-kb human Id-1 promoter revealed that activating transcription factor 3 (ATF3) and
Smad interaction, with their respective binding motifs, was
essential for REIC/Dkk-3 mediated suppression of
Id-1 promoter activity ... In summary, we first showed that both ATF3 and
Smad were crucially and synergistically
involved in down-regulation of
Id-1 , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis
Liang et al., Cell Res 2009
:
Smad3 mediates immediate early induction of
Id1 by TGF-beta ... Our results demonstrate that
Smad3 , but not Smad2,
mediates TGF-beta1 dependent early transcriptional induction of
Id1