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IFI27 — IGF1

Text-mined interactions from Literome

Jia et al., Immunol Cell Biol 2006 (Atherosclerosis...) : IGF-1 markedly inhibited the expression of p27 ( kip ) and p21 ( cip ) and significantly induced cyclin E and cyclin D ... On the contrary, in symptomatic VSMC there was already increased apoptosis of VSMC and there was no significant effect of IGF-1 or inflammatory cytokines on proliferation, apoptosis or the expression of p27 ( kip ) and p21 ( cip ) and cyclin D and E
Fukushima et al., Endocrinology 2008 : Furthermore, cAMP pretreatment enhanced IGF-I induced protein degradation of the CDK inhibitor, p27 ( Kip1 ) ... In contrast, IGF-I dependent PI 3-kinase activation was required for the increase in cyclin D1 mRNA levels and degradation of p27 ( Kip1 )