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ESR1 — NOS2

Text-mined interactions from Literome

Simoncini et al., Arterioscler Thromb Vasc Biol 2003 : By interacting with phosphatidylinositol 3-kinase (PI3K), estrogen receptor (ER) alpha leads to activation of protein kinase Akt and to subsequent increase in endothelial nitric oxide synthase activity
Kumar et al., Mol Endocrinol 2007 : In endothelial cells, the disruption of ER alpha-G alpha i interaction prevents estradiol induced nitric oxide synthase activation and the resulting attenuation of monocyte adhesion that contributes to estrogen related cardiovascular protection
Tsutsumi et al., J Endocrinol 2008 : Here, we report studies to examine the differential regulation of NOS2A gene expression by ESR1 and 2 ... In heterologous expression studies of COS-7 cells lacking endogenous ER, E ( 2 ) treatment of COS-7 cells did not alter NOS2A reporter activity in the presence of ESR1 , while reporter activity increased 2.3-fold in the presence of ESR2
Cignarella et al., J Pharmacol Exp Ther 2009 (Diabetes Mellitus, Experimental...) : Distinct roles of estrogen receptor-alpha and beta in the modulation of vascular inducible nitric-oxide synthase in diabetes ... In cultured aortic rings from both normoglycemic and STZ-diabetic mice, pharmacological activation of ER alpha attenuated cytokine-driven iNOS induction by 30 to 50 %
Fan et al., J Steroid Biochem Mol Biol 2009 : The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS