Gene interactions and pathways from curated databases and text-mining

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ECE1 — EPHB2

Text-mined interactions from Literome

Eto et al., Circ Res 2001 : On the other hand, inhibition of ERK1 and ERK2 activation by PD98059 ( 50 micromol/L ) prevented the upregulation of ECE-1 expression by thrombin as well as the increase in ECE activity and ET-1 accumulation in the medium
Khimji et al., Am J Pathol 2008 (Liver Diseases) : In addition, inhibition of ERK activation in stellate cells from BDL injured liver led to a decrease in expression of endothelin converting enzyme-1 , a critical regulator of endothelin-1
Cottrell et al., J Biol Chem 2009 (MAP Kinase Signaling System) : ECE-1 inhibition caused endosomal retention of the SP neurokinin 1 receptor, beta-arrestins, and Src, resulting in markedly sustained ERK2 activation in the cytosol and nucleus, whereas ECE-1 overexpression attenuated ERK2 activation