◀ Back to CDH1

CDH1 — SKP2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CDH1 — SKP2 (direct interaction, pull down) Gao et al., Nat Cell Biol 2009*
• IRef Biogrid Interaction: CDH1 — SKP2 (physical association, affinity chromatography technology) Gao et al., Nat Cell Biol 2009*
• IRef Biogrid Interaction: CDH1 — SKP2 (direct interaction, pull down) Inuzuka et al., Cell 2012
• IRef Biogrid Interaction: CDH1 — SKP2 (physical association, affinity chromatography technology) Inuzuka et al., Cell 2012
• MIPS CORUM CDH1-SKP2 complex: CDH1-SKP2 complex complex (CDH1-SKP2) Bashir et al., Nature 2004*
• IRef Corum Interaction: SKP2 — CDH1 (association, coimmunoprecipitation) Bashir et al., Nature 2004*
• IRef Intact Interaction: SKP2 — CDH1 (physical association, anti tag coimmunoprecipitation) Inuzuka et al., Cell 2012

Text-mined interactions from Literome

Bashir et al., Nature 2004 : Silencing of Cdh1 by RNA interference in G1 cells stabilizes Skp2 and Cks1, with a consequent increase in p21 and p27 proteolysis
Liu et al., Mol Cell Biol 2007 : The Skp2 degradation is mediated by Cdh1-anaphase promoting complex (APC), as shown by depletion of Cdh1 with small interfering RNA, and by reconstitution of ubiquitylation reactions in a purified system
Lwin et al., Blood 2007 (Lymphoma, B-Cell...) : Furthermore, we found cell adhesion up-regulated Cdh1 ( an activating subunit of anaphase promoting complex [ APC ] ubiquitin ligase ), and reduction of Cdh1 by siRNA induced Skp2 accumulation and hence p27 ( Kip1 ) degradation, thus implicating Cdh1 as an upstream effector of the Skp2/p27 ( Kip1 ) signaling pathway
Cuende et al., Oncogene 2008 (Neuroblastoma) : Furthermore, either Rae1 overexpression or Cdh1 inhibition promoted Skp2 accumulation, p27 destabilization and prevented retinoic acid induced cell cycle arrest and differentiation