◀ Back to CCR5
CCR5 — IL18
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Biasin et al., J Infect Dis 2000
:
However,
interleukin (IL)-6 , IL-10, IL-12, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha and -beta mRNA were elevated in PBMC and cervical mucosa biopsy specimens of ESN and HIV infected women ;
CCR5 and CXCR4 mRNA were
augmented in cervical mucosa biopsy specimens, but not in PBMC, of ESN and HIV infected women ; HIV-specific IFN-gamma secreting cells were detected in vaginal washes of ESN and HIV infected women ; and phenotypic alterations were present in PBMC of ESN women
Rodriguez-Galán et al., J Immunol 2005
:
Additionally,
IL-18 in combination with IL-2
induces CCR4 ( Th2 associated ) and
CCR5 ( Th1 associated ) gene expression ... In contrast,
IL-18-plus-IL-12 specifically
induced CCR5 expression
Zhang et al., Arthritis Rheum 2005
(Arthritis, Rheumatoid) :
In contrast,
interleukin-12 stimulation
induced the up-regulation of
CCR5 and a shift in the in vivo homing pattern away from the lymph nodes toward the inflamed synovium