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CCL3 — MAPK12
Text-mined interactions from Literome
Majka et al., Stem Cells 2000
:
In contrast, the CCR5 ligands (
macrophage inflammatory protein-1alpha [ MIP-1alpha ], MIP-1beta, and RANTES ) did not
activate calcium flux,
MAPK and AKT phosphorylation or chemotaxis of CD34 ( + ) KIT ( + ) cells or cells isolated from the BFU-E colonies
Sakai et al., Nephrol Dial Transplant 2002
(Glomerulonephritis) :
We conclude that the phosphorylation of p38
MAPK associated with the activation of NF-kappa B may be
involved in the upregulation of intrarenal
MIP-1 alpha and the utilization of CCR5 signalling, which may result in human crescentic glomerulonephritis
Ottonello et al., Cell Signal 2005
:
When the
activation of ERK-1/2 and p38
MAPK by
CCL3 and the classical neutrophilic chemokine CXCL8 ( IL-8 ) were compared, both the chemokines were capable of activating p38 MAPK
Wong et al., Am J Respir Cell Mol Biol 2005
:
IL-25 could also activate the JNK, p38 MAPK, and NF-kappaB activities of eosinophils, while inhibitor of IkappaB-alpha phosphorylation ( BAY11-7082 ), JNK ( SP600125 ), and p38
MAPK ( SB203580 ) could
suppress the release of IL-8,
MIP-1alpha , MCP-1, and IL-6 ... Together, the above results showed that the induction of MCP-1,
MIP-1alpha , IL-8, and IL-6 in IL-25 activated eosinophils are
regulated by JNK, p38
MAPK , and NF-kappaB pathways
Masih-Khan et al., Blood 2006
(Bone Diseases...) :
Down-regulation of MIP-1 alpha was not, however, observed following FGFR3 inhibition in MM cells with RAS mutations implicating
RAS-MAPK in
MIP-1 alpha regulation
Wang et al., Arthritis Rheum 2013
(Intervertebral Disc Degeneration...) :
Transfections were used to determine the
role of NF-?B, CCAAT/enhancer binding protein ( C/EBPß ), and
MAPK on cytokine mediated
CCL3 promoter activity
Tian et al., Am J Physiol 1998
:
However, in contrast to the wild-type endotoxin, it failed to induce significant production of tumor necrosis factor-alpha and
macrophage inflammatory protein-1alpha by monocytes and did not
induce the phosphorylation and nuclear translocation of
mitogen activated protein kinase