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CDKN1A — CREB3

Text-mined interactions from Literome

Arnould et al., EMBO J 2002 : Finally, our data suggest that phosphorylated CREB recruits p53 tumor suppressor protein, modifies its transcriptional activity and increases the expression of p21 ( Waf1/Cip1 ), a p53 regulated cyclin dependent kinase inhibitor
Zhang et al., Cell Death Differ 2008 (Second Messenger Systems) : The induction of the long form of cellular FLICE-inhibitory protein ( c-FLIP ( L ) ) and mitogen activated protein kinase phosphatase-1 ( MKP-1 ), but not DLC and p21 ( WAF1 ) by CREB was required for cAMP mediated inhibition of JNK activation
Begum et al., J Biol Chem 2011 (MAP Kinase Signaling System) : We conclude that PDE3A regulates VSMC growth via two complementary pathways, i.e. PKA catalyzed inhibitory phosphorylation of Raf-1 with resulting inhibition of MAPK signaling and PKA/CREB mediated induction of p21 , leading to G0/G1 cell cycle arrest, as well as by increased accumulation of p53, which induces MKP-1, p21, and WIP1, leading to inhibition of G1 to S cell cycle progression
Yang et al., J Biol Chem 2013 : Interactions of these specific regions of Smad4 and PKA-R were necessary for TGFß mediated increases in PKA activity, CREB ( cAMP-response element binding protein ) phosphorylation, induction of p21 , and growth inhibition