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TGFB2 — THBS2

Text-mined interactions from Literome

Fuchshofer et al., Invest Ophthalmol Vis Sci 2005 : To study whether glaucomatous extracellular matrix ( ECM ) modifications in the lamina cribrosa might be induced by TGF-beta 2, the effect of TGF-beta 2 on the expression of collagen types I ( Col1 alpha 1 ), III ( Col3 alpha 1 ), and IV ( Col4 alpha 2 ) ; fibronectin ( FN ) ; tissue transglutaminase ( TGM2 ) ; connective tissue growth factor (CTGF) ; and thrombospondin ( TSP-1 ) in cultured human optic nerve head ( ONH ) astrocytes was investigated
Hsu et al., Cancer Res 1996 (Brain Neoplasms...) : This change in angiogenesis was directly due to the increased secretion of a potent inhibitor of angiogenesis, thrombospondin-1, because : ( a ) neutralizing thrombospondin completely relieved the inhibition ; ( b ) the inhibitory activity of thrombospondin was not dependent on transforming growth factor beta ; and ( c ) chromosome 10 introduction did not alter secreted inducing activity
Basile et al., Curr Opin Nephrol Hypertens 1999 (Kidney Diseases) : Both in-vitro and in-vivo studies have demonstrated that proteolytic activity, thrombospondin-1 , elevated glucose, angiotensin II, oxidant stress and hemodynamic forces regulate transforming growth factor beta activity through both transcriptional and post-transcriptional mechanisms