Gene interactions and pathways from curated databases and text-mining

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FYN — IL2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Yamakami et al., Environ Health Prev Med 2001 : Fyn appears to play a role in the activation of T cells based on its enzymatic activation and tyrosine phosphorylation following the ligation of TCR/CD3, and it also plays a critical role in the calcium flux and interleukin-2 (IL-2) production
Brizuela et al., Eur J Immunol 1995 : Induction of interleukin-2 transcription by the hamster polyomavirus middle T antigen : a role for Fyn in T cell signal transduction ... Furthermore, dominant negative Fyn but not the equivalent allele of Lck blocked HamT activation of IL-2 transcription, while both Lck and Fyn dominant negative alleles blocked LT cell receptor mediated IL-2 transcriptional activation
Sancho et al., J Immunol 1993 : Anti-TCR/CD3 stimulation of the TCR/CD3+ J32-3.2 cells resulted in a weak stimulation of both the phosphatidyl inositol and tyrosine kinase signal transduction pathways, as measured by changes in the level of free intracellular calcium, tyrosine phosphorylation of TCR-zeta, CD3-epsilon and ZAP-70, p56lck, or p59fyn tyrosine kinase activity and IL-2 gene activation
Takeuchi et al., J Biol Chem 1993 : Interestingly, a mutant Fyn , which has deletions within the SH2 region and so is able to transform chicken embryo fibroblasts, did not stimulate either the c-fos or IL-2 promoter, suggesting the importance of this region in T-cell signaling ... Csk, which phosphorylates tyrosine residues in the negative regulatory sites of Src family kinases, down-regulated Fyn- and Lck mediated stimulation of the serum response element and Fyn mediated enhancement of IL-2 promoter activity
Kobayashi et al., Proc Natl Acad Sci U S A 1993 : We observed that in this cell line, IL-2 induces activation of at least two src-PTKs, p59fyn ( fyn ) and p53/56lyn ( lyn )