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FYN — IL2
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3)
→
IL2/IL2R beta/gamma/JAK1/Fyn/JAK3/PI3K complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3-PIK3CA-PIK3R1)
(modification, collaborate)
Augustine et al., Mol Cell Biol 1991
Evidence: assay, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Augustine et al., Mol Cell Biol 1991
Evidence: assay, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R beta/gamma/JAK1/Fyn/JAK3/PI3K complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3-PIK3CA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Augustine et al., Mol Cell Biol 1991
Evidence: assay, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3)
→
IL2 (IL2)
(modification, collaborate)
Kobayashi et al., Proc Natl Acad Sci U S A 1993
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3)
→
IL2R gamma/JAK3 complex (IL2RG-JAK3)
(modification, collaborate)
Kobayashi et al., Proc Natl Acad Sci U S A 1993
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3)
→
IL2R beta/JAK1/Fyn complex (IL2RB-JAK1-FYN)
(modification, collaborate)
Kobayashi et al., Proc Natl Acad Sci U S A 1993
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2 (IL2)
→
IL2R beta/JAK1/Fyn complex (IL2RB-JAK1-FYN)
(modification, collaborate)
Kobayashi et al., Proc Natl Acad Sci U S A 1993
Evidence: assay, physical interaction, other species
Text-mined interactions from Literome
Yamakami et al., Environ Health Prev Med 2001
:
Fyn appears to play a role in the activation of T cells based on its enzymatic activation and tyrosine phosphorylation following the ligation of TCR/CD3, and it also
plays a critical role in the calcium flux and
interleukin-2 (IL-2) production
Brizuela et al., Eur J Immunol 1995
:
Induction of
interleukin-2 transcription by the hamster polyomavirus middle T antigen : a
role for
Fyn in T cell signal transduction ... Furthermore, dominant negative
Fyn but not the equivalent allele of Lck
blocked HamT activation of
IL-2 transcription, while both Lck and Fyn dominant negative alleles blocked LT cell receptor mediated IL-2 transcriptional activation
Sancho et al., J Immunol 1993
:
Anti-TCR/CD3 stimulation of the TCR/CD3+ J32-3.2 cells resulted in a weak stimulation of both the phosphatidyl inositol and tyrosine kinase signal transduction pathways, as measured by changes in the level of free intracellular calcium, tyrosine phosphorylation of TCR-zeta, CD3-epsilon and ZAP-70, p56lck, or
p59fyn tyrosine kinase activity and
IL-2 gene
activation
Takeuchi et al., J Biol Chem 1993
:
Interestingly, a mutant
Fyn , which has deletions within the SH2 region and so is able to transform chicken embryo fibroblasts, did not
stimulate either the c-fos or
IL-2 promoter, suggesting the importance of this region in T-cell signaling ... Csk, which phosphorylates tyrosine residues in the negative regulatory sites of Src family kinases, down-regulated Fyn- and Lck mediated stimulation of the serum response element and
Fyn mediated enhancement of
IL-2 promoter activity
Kobayashi et al., Proc Natl Acad Sci U S A 1993
:
We observed that in this cell line,
IL-2 induces activation of at least two src-PTKs,
p59fyn ( fyn ) and p53/56lyn ( lyn )