Gene interactions and pathways from curated databases and text-mining

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ACE — NPPA

Text-mined interactions from Literome

Nyström et al., Scand J Clin Lab Invest 1998 : ACE correlated negatively with cGMP in men ( all ; r = -0.22, p = 0.03, 45-69 years of age r = -0.49, p = 0.0002 ) and this correlation was independent of ANP , ACE, ABP and age
Hu et al., Basic Res Cardiol 2001 (Myocardial Infarction) : The effects of angiotensin converting enzyme (ACE) inhibition ( quinapril, 6 mg/kg/day ) and angiotensin II type 1 (AT1) receptor blockade ( losartan, 10 mg/kg/day ) on ANP levels in 18 selected, microdissected brain nuclei were determined in sham operated rats and rats with left ventricular dysfunction 8 weeks after myocardial infarction ( MI )
Heintz et al., Clin Physiol Biochem 1992 (Heart Failure) : Conclusion : ACE inhibition does not induce changes in ANP or ADH levels in the resting state while Ang II decreases
Cockcroft et al., J Hum Hypertens 1989 : This has been investigated within the forearm vascular bed during local ANP infusion and ACE inhibition
Saijonmaa et al., Cardiovasc Res 1998 : To examine the role of atrial natriuretic peptide (ANP) and cyclic GMP in the regulation of angiotensin converting enzyme (ACE) in cultured human endothelial cells ... ANP caused a dose dependent increase in ACE measured in intact endothelial cell culture ... These data suggest that cGMP is an intracellular mediator regulating ACE and that ANP induced increase of ACE is mediated via a cGMP dependent mechanism