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FOS — PTGS2
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Allport et al., Mol Hum Reprod 2000
:
NF-kappaB and
AP-1 are
required for
cyclo-oxygenase 2 gene expression in amnion epithelial cell line ( WISH )
Ogasawara et al., J Biol Chem 2001
:
These data suggest that C/EBP beta,
AP-1 , and CREB
play crucial roles in the shear stress induced
cox-2 expression in osteoblasts
Guo et al., J Biol Chem 2001
(Cell Transformation, Neoplastic...) :
Bombesin stimulation of
COX-2 expression
requires an increase in [ Ca ( 2+ ) ] ( i ), activation of extracellular signal regulated kinase ( ERK ) -1 and -2 and p38 ( MAPK ), and increased activation and expression of the transcription factors Elk-1, ATF-2,
c-Fos , and c-Jun
Hsu et al., J Immunol 2001
:
In conclusion, we suggest that ceramide inhibition of LPS mediated induction of inducible NO synthase and
cyclooxygenase-2 is
due to reduction of the activation of NF-kappaB and
AP-1 , which might result from ceramide 's inhibition of LPS stimulated IkappaB kinase, p38 mitogen activated protein kinase, and protein kinase C
Subbaramaiah et al., Cancer Res 2002
:
The induction of
COX-2 transcription by PMA was
mediated by increased binding of
AP-1 to the cyclic AMP response element ( CRE ) of the COX-2 promoter ... Thus, RA acted by a receptor dependent mechanism to limit the amount of CBP/p300 that was available for
AP-1 mediated induction of
COX-2 ... By contrast, carnosol
inhibited the induction of
COX-2 by blocking PKC signaling and thereby the binding of
AP-1 to the CRE of the COX-2 promoter
Lee et al., Br J Pharmacol 2003
:
The effects of sauchinone on the inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and
cyclooxygenase 2 (COX-2) gene expression and on the
activation of transcription factors, nuclear factor-kappaB (NF-kappaB), CCAAT/enhancer binding protein (C/EBP),
activator protein-1 (AP-1) and cAMP-response element binding protein ( CREB ) were determined in Raw264.7 cells as part of the studies on its anti-inflammatory effects
Zhang et al., J Comp Neurol 2003
(Fever) :
Specific
roles of cyclooxygenase-1 and
cyclooxygenase-2 in lipopolysaccharide induced fever and
Fos expression in rat brain
Chun et al., Carcinogenesis 2004
:
Celecoxib inhibits phorbol ester induced expression of
COX-2 and
activation of
AP-1 and p38 MAP kinase in mouse skin
Grau et al., Cancer Res 2004
(Colonic Neoplasms) :
This cyclopentenone was able to inhibit
activator protein1 (AP-1) dependent transcriptional
induction of
COX-2 and VEGF promoters induced by phorbol 12-myristate 13-acetate ( PMA ) or c-Jun overexpression
Chen et al., Mol Pharmacol 2005
:
Furthermore, we demonstrated that
c-Fos , which provides transactivation function in Jun/Fos heterodimer, was
required for EGF induced expression of
COX-2
Hwang et al., J Biol Chem 2005
:
Here, we investigated the
role of c-Jun and
activator protein-1 (AP-1) in IL-1beta induced dedifferentiation and cyclooxygenase
(COX)-2 expression in primary cultured chondrocytes
Yamaguchi et al., J Biol Chem 2005
:
We investigated whether HDAC inhibitors blocked
AP-1 mediated
activation of
COX-2 transcription ... Trichostatin A and suberoylanilide hydroxamic acid, two structurally related inhibitors of HDAC activity, blocked
AP-1 mediated
induction of
COX-2 expression and prostaglandin E2 biosynthesis
Cho et al., Exp Mol Med 2005
:
Curcumin
inhibits the expression of
COX-2 in UVB irradiated human keratinocytes ( HaCaT ) by inhibiting activation of
AP-1 : p38 MAP kinase and JNK as potential upstream targets
Li et al., Free Radic Biol Med 2005
:
These results suggest that excessive NO production during inflammation induces apoptosis in PC12 cells through
AP-1 mediated upregulation of
COX-2 expression
Uenoyama et al., Oncogene 2006
(Anoxia...) :
Furthermore,
COX-2 expression was also
reduced by the inhibition of transcription factor
AP-1
Degner et al., J Nutr 2006
(Breast Neoplasms) :
Collectively, these results suggest that CLA represses
AP-1 mediated activation of
COX-2 transcription
Zhang et al., Carcinogenesis 2007
:
Further investigation revealed that JNK1 mediated the nickel induced
COX-2 expression in a
c-Jun/AP-1 dependent manner
Lee et al., Carcinogenesis 2007
(MAP Kinase Signaling System) :
Humulone
inhibits phorbol ester induced
COX-2 expression in mouse skin by blocking activation of NF-kappaB and
AP-1 : IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets
Park et al., Ann N Y Acad Sci 2007
:
KG-135
inhibits COX-2 expression by blocking the activation of JNK and
AP-1 in phorbol ester stimulated human breast epithelial cells
Song et al., Gut 2007
(Adenocarcinoma...) :
Unconjugated bile acids induce CREB and
AP-1 dependent
COX-2 expression in Barrett 's oesophagus and OA through ROS mediated activation of PI3K/AKT and ERK1/2
Kim et al., Carcinogenesis 2008
(Breast Neoplasms) :
15d-PGJ ( 2 ) -induced
COX-2 expression was
mediated by activation of Akt and subsequently
activator protein-1 (AP-1)
Lee et al., Anesth Analg 2008
(Hyperalgesia...) :
The
effects of intrathecal cyclooxygenase-1,
cyclooxygenase-2 , or nonselective inhibitors on pain behavior and spinal
Fos-like immunoreactivity
Healy et al., Am J Physiol Cell Physiol 2008
:
Deletion and mutation analyses of the human cox-2 promoter reveal that the CCAAT/enhancer binding protein (C/EBP) and
activator protein-1 (AP-1) predominantly
contribute to the shear induced
cox-2 promoter activity
Hsieh et al., Biochim Biophys Acta 2008
:
Moreover, thrombin stimulated
activation of NF-kappaB, AP-1, and
COX-2 promoter activity was blocked by the inhibitors of c-Src, PKC, EGFR, MEK1/2,
AP-1 and NF-kappaB, suggesting that thrombin induces COX-2 promoter activity mediated through PKC ( delta ) /c-Src dependent EGFR transactivation, MEK-ERK1/2, AP-1, and NF-kappaB
Bianchi et al., Neurobiol Aging 2010
(Encephalitis...) :
We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via RAGE dependent activation of JNK ; ( 2 ) S100B upregulates IL-1beta and TNF-alpha expression in microglia via RAGE engagement ; and ( 3 ) S100B/RAGE induced upregulation of
COX-2 , IL-1beta and TNF-alpha expression
requires the concurrent activation of NF-kappaB and
AP-1
Kim et al., Carcinogenesis 2009
(Uterine Cervical Neoplasms) :
Involvement of NF-kappaB and
AP-1 in
COX-2 upregulation by human papillomavirus 16 E5 oncoprotein
Cho et al., Dig Dis Sci 2010
(Adenocarcinoma...) :
Involvement of Ras and
AP-1 in Helicobacter pylori
induced expression of
COX-2 and iNOS in gastric epithelial AGS cells ... We investigated whether H. pylori in a Korean isolate ( HP99 ), a cagA ( + ), vacA ( + ) strain, induces the expression of c-Fos and c-Jun for AP-1 activation to induce COX-2 and iNOS and whether HP99 induced expressions of
COX-2 and iNOS are
mediated by Ras and
AP-1 , determined by the expressions of c-Fos and c-Jun, in gastric epithelial AGS cells, using transfection with mutant genes for Ras ( ras N-17 ) and c-Jun ( TAM-67 )
Han et al., Food Chem Toxicol 2010
:
Thus, DHCT is an effective agent to attenuate
COX-2 production
mediated by the transcription factors C/EBP and
AP-1 , and these results enhance our understanding of the anti-inflammatory and anti-cancer properties by DHCT
Shrotriya et al., Cancer Res 2010
(Skin Neoplasms) :
Diallyl trisulfide inhibits phorbol ester induced tumor promotion,
activation of
AP-1 , and expression of
COX-2 in mouse skin by blocking JNK and Akt signaling ... Pharmacologic inhibition of JNK or Akt by SP600125 or LY294002, respectively, resulted in diminished
AP-1 DNA binding, reduced levels of c-Jun and c-Fos, and
inhibition of
COX-2 expression in TPA treated mouse skin
Nadjar et al., Neurobiol Dis 2010
:
Central
cyclooxygenase-2 inhibition
attenuated extracellular signal regulated kinase-1/2 phosphorylation and
c-Fos induction in the median preoptic area and arcuate hypothalamus, but not in other hypothalamic or brainstem structures, after intraperitoneal interleukin-1beta administration
Lim et al., Biochem Pharmacol 2011
:
By using PP2, a pharmacological inhibitor for SFKs, we showed that Fyn kinase
regulates B [ a ] PDE induced
COX-2 expression by activating MAPKs,
AP-1 and NF-?B
Chen et al., Cell Microbiol 2011
:
Inhibition of NF-?B and
AP-1 activations
blocked the J96-1 induced
COX-2 promoter activity and expression
Tsai et al., J Dermatol Sci 2013
(Gram-Positive Bacterial Infections...) :
ROS dependent stimulation of ERK, JNK, NF-?B, and
AP-1 activation
contributes to P. acnes induced iNOS/NO and
COX-2/PGE ( 2 ) in macrophages, and chemicals such as hispolon possessing ability to block iNOS/NO and COX-2/PGE ( 2 ) production reserve potential to be further developed for treatment of the early phase of inflammation elicited by P. acnes
Buritova et al., Brain Res 1996
(Edema) :
Selective
cyclooxygenase-2 inhibition
reduces carrageenan oedema and associated spinal
c-Fos expression in the rat
Zhang et al., J Biol Chem 1998
:
Because other activators of PKC and
AP-1 induce
cyclooxygenase-2 (COX-2) , we determined the effects of bile acids on the expression of COX-2 in human esophageal adenocarcinoma cells
von Knethen et al., Mol Biol Cell 1999
:
Whereas cytokine mediated Cox-2 induction relies on NF-kappaB activation, a low-level NO-elicited
Cox-2 response
required activation of both NF-kappaB and
AP-1