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GADD45A — TP53
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Daino et al., J Radiat Res 2003
:
It is known that induction of the
GADD45a gene is regulated in a
p53 dependent manner after ionizing irradiation
Daino et al., Biochim Biophys Acta 2006
:
It is generally thought that induction of the
GADD45A gene after IR exposure is principally
p53 dependent , requiring binding of the p53 protein to the p53-recognition sequence in the third intron
Tront et al., Cancer Res 2010
(Mammary Neoplasms, Animal...) :
Because
Gadd45a is a
target for BRCA1 and
p53 , these findings have implications regarding BRCA1/p53 tumor suppressor functions
Satoh et al., Leukemia 2012
(Leukemia, Myeloid, Acute...) :
As for this mechanism, we found that RUNX1 directly regulates the transcription of
GADD45A and that RUNX1 and
p53 synergistically
activate the GADD45A transcription