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MIF — TP53
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
TP53
→
MIF
(decreases)
Evidence: MIF has been described to downregulate basic and phosphorylated p53 expression (Figure 2), resulting in inhibition of apoptosis and prolonged survival of macrophages in particular after cellular stress.49,50
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Mitchell et al., Proc Natl Acad Sci U S A 2002
:
MIF inhibits
p53 activity in macrophages via an autocrine regulatory pathway, resulting in a decrease in cellular p53 accumulation and subsequent function ... Inhibition of p53 by MIF coincides with the induction of arachidonic acid metabolism and cyclooxygenase-2 (Cox-2) expression, which is required for
MIF regulation of
p53
Oda et al., PloS one 2008
:
Macrophage migration inhibitory factor activates hypoxia-inducible factor in a
p53 dependent manner ...
MIF regulates HIF-1 activity in a
p53 dependent manner
Jung et al., J Biol Chem 2008
:
Direct interaction between NM23-H1 and macrophage migration inhibitory factor ( MIF ) is critical for alleviation of
MIF mediated suppression of
p53 activity
Gesser et al., Inflamm Res 2011
(Psoriasis) :
The effects of DMF on the
MIF induced
activation of MSK1, RSK1, cAMP-responsive element binding protein ( CREB ), Cox-2 and c-Jun, JunB and
p53 were studied by Western blotting using phospho-specific antibodies