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TP53 — VDR
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Maruyama et al., Cancer Res 2006
:
VDR is
induced by
p53 as well as several other p53 family members, and analysis of chromatin immunoprecipitation showed that p53 protein binds to conserved intronic sequences of the VDR gene in vivo ... In addition,
p53 induced
VDR target genes in a vitamin D3-dependent manner
Kommagani et al., J Biol Chem 2007
:
Differential
regulation of
vitamin D receptor (VDR) by the
p53 Family : p73 dependent induction of VDR upon DNA damage ... In this report, we examined whether
p53 affects p63 mediated induction of
VDR and studied the effect of DNA damage on VDR induction in p53 null cell lines ... Our results demonstrate that
p53 itself does not
induce VDR expression, nor does it affect p63 mediated VDR induction in the cell lines tested in this study
Sequeira et al., Mol Endocrinol 2012
:
This up-regulation of p53, however, was observed in all mutant fibroblasts, including those with no VDR, and with Ab099 ; therefore,
VDR and ERp57 are not
essential for
p53 regulation