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MAPK1 — RARA
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Retinoic acid receptors-mediated signaling:
Erk1-2-active (MAPK3/MAPK1)
→
RXRs/RARs/NRIP1/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1)
(modification, activates)
Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database Retinoic acid receptors-mediated signaling:
Erk1-2-active (MAPK3/MAPK1)
→
RXRs/RARs complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA)
(modification, activates)
Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database Retinoic acid receptors-mediated signaling:
Erk1-2-active (MAPK3/MAPK1)
→
RXRs/RARs/SMRT(N-CoR2)/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NCOR2)
(modification, activates)
Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
Evidence: mutant phenotype, assay, physical interaction, other species
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Braun et al., Biol Reprod 2002
:
Positive
regulation of
retinoic acid receptor alpha by protein kinase C and
mitogen activated protein kinase in sertoli cells
Chai et al., IUBMB Life 2009
:
The current study investigated a possible
role for p38
MAPK in the regulation of ( SRC ) -3 phosphorylation/degradation and in
retinoic acid receptor (RAR)alpha signaling in mouse fetal cortical neurons treated with all-trans retinoic acid ( ATRA ) ... Inhibition of p38
MAPK significantly
enhanced the
RARalpha-RARE binding activity, but had no effects on ATRA induced decrease of RARalpha