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PPP2CA — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
PPP2CA
—
TP53
Zhao et al., Mol Cancer Res 2003*
-
IRef Bind_translation Interaction:
PPP2CA
—
TP53
(affinity chromatography technology)
Zhao et al., Mol Cancer Res 2003*
-
IRef Hprd Interaction:
TP53
—
PPP2CA
(in vitro)
Zhao et al., Mol Cancer Res 2003*
-
IRef Intact Interaction:
Complex of 244 proteins
(association, pull down)
Komarova et al., Mol Cell Proteomics 2011
-
IRef Intact Interaction:
Complex of MDM2-PPP2CA-PPP2R5C-TP53
(association, anti bait coimmunoprecipitation)
Shouse et al., Oncogene 2011*
-
IRef Intact Interaction:
Complex of PPP2R5C-TP53-PPP2CA
(association, anti tag coimmunoprecipitation)
Shouse et al., Oncogene 2011*
-
IRef Ophid Interaction:
PPP2CA
—
TP53
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Okamoto et al., Mol Cell 2002
:
Thus, our data suggest that cyclin G recruits
PP2A in order to modulate the phosphorylation of Mdm2 and thereby to
regulate both Mdm2 and
p53
Messner et al., J Cell Biochem 2006
:
Inhibition of
PP2A , but not PP5,
mediates p53 activation by low levels of okadaic acid in rat liver epithelial cells
Gwinn et al., Mol Cell 2013
:
In this issue of Molecular Cell, Reid et al. ( 2013 ) show that glutamine withdrawal causes
PP2A mediated activation of
p53 through its regulator EDD, linking levels of a critical metabolite to an important regulator of cell survival and proliferation