Gene interactions and pathways from curated databases and text-mining

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GDNF — TNF

Text-mined interactions from Literome

Ivanov et al., Oncogene 2000 (Melanoma) : We recently demonstrated that through up-regulation of TNFalpha , ATF2 increases the resistance of late stage melanoma cells to apoptosis induced by UV-irradiation
Gotohda et al., Leg Med (Tokyo) 2002 : In the cerebellum, TNF-alpha was induced only in the granule cells, while GDNF expression was enhanced in the Purkinje cells
Rémy et al., Neuroreport 2003 : Lipopolysaccharide and TNFalpha regulate the expression of GDNF , neurturin and their receptors
Suganami et al., Circ Res 2009 (Inflammation...) : Importantly, ATF3 , when induced by saturated fatty acids, can transcriptionally repress tumor necrosis factor-alpha production in macrophages in vitro
Spinnler et al., Hum Reprod 2010 (Fibrosis...) : We also tested whether GDNF production is regulated by tumour necrosis factor-alpha (TNF-alpha) or tryptase, the products of mast cells or macrophages ... TNF-alpha and tryptase had no effect on the secretion of GDNF by HTPCs or HTPC-Fs
Zhang et al., J Pathol 2010 (Colitis...) : Our results showed that GDNF resulted in a significant reduction in enhanced permeability, inhibited MPO activity, IL-1beta and TNF-alpha expression, and increased ZO-1 and Akt expression
Lopes et al., Pharm Biol 2010 (Inflammation) : The effects of Alchornea triplinervia ethyl acetate fraction (AtF) on hydrogen peroxide ( H2O2 ), nitric oxide ( NO ) and tumor necrosis factor-a (TNF-a) production in peritoneal macrophages were investigated using phenol red, Griess reagent and a sandwich immunoassay, respectively
Chertoff et al., Exp Neurol 2011 (Chronic Disease...) : Protective effects of low TNF-a level could be mediated by TNF-R1, GDNF , and IGF-1 in the SN and SOD activity in the striatum ( ST )
Lee et al., J Nutr Biochem 2013 (Pneumonia) : In addition, EGCG also attenuated TNF-a induced oxidative stress, p47(phox) translocation, MAPKs activation, and STAT-3 and activating transcription factor (ATF)2 phosphorylation
Pan et al., J Biol Chem 1998 : These data indicate that the kappaB sites and the variant ATF/CRE are required for TNF-alpha or LPS to optimally induce expression of the murine P-selectin gene