◀ Back to TRAF2
BIRC3 — TRAF2
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
O/k complex ()
→
Complex of BIRC2-BIRC3-TRAF1-TRAF2
(increases, BIRC2/BIRC3/TRAF1/TRAF2 Activity)
Evidence: a dimeric Smac/DIABLO molecule is required for binding to BIR2, but not to BIR3, which indicates significant differences in the affinity or mechanism by which Smac/DIABLO binds to these domains Figure 5: Association of IAPs with signalling complexes.
-
BioCarta sodd/tnfr1 signaling pathway:
SODD (BAG4)
→
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
MADD
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TRADD
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
cIAP2 (BIRC3)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TRAF2
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
RAIDD (CRADD)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
cIAP2 (BIRC3)
→
TRAF2
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
Caspase 2 (active) (CASP2)
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
Caspase 2 (CASP2)
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
JNKK1 (MAP2K4)
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
FADD
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
FADD/Caspase 8 complex (CASP8-FADD)
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
Caspase 8 (CASP8)
(modification, activates)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
MADD
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
cIAP2 (BIRC3)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TRADD
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
RAIDD (CRADD)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TRAF2
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
SODD (BAG4)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
cIAP2 (BIRC3)
→
TRAF2
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
FADD/Caspase 8 complex (CASP8-FADD)
→
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
SODD (BAG4)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
cIAP2 (BIRC3)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
TNF-alpha/TNF R1/SODD complex (BAG4-TNFRSF1A-TNF)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
TRADD
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
MADD
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
TRAF2
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
RAIDD (CRADD)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
cIAP2 (BIRC3)
→
TRAF2
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TRAF1
→
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
RAIDD (CRADD)
→
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
SODD (BAG4)
→
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
cIAP2 (BIRC3)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
ASK1 (MAP3K5)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
TRADD
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
TRAF2
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
Caspase 2 (CASP2)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
FADD
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
cIAP2 (BIRC3)
→
TRAF2
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
(modification, activates)
Micheau et al., Cell 2003, Yang et al., Cell 1997, Saitoh et al., EMBO J 1998, Chang et al., Science 1998
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
RAIDD (CRADD)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
FADD (FADD)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
ASK1 (MAP3K5)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TRAF1 (TRAF1)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
cIAP2 (BIRC3)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
cIAP2 (BIRC3)
→
TRAF2 (TRAF2)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
BAG4 (BAG4)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
Caspase 2 (CASP2)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/BAG4/TNF-alpha complex (TNF-BAG4-TNFRSF1A)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
TRADD (TRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
RIP (RIPK1)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
TRAF2 (TRAF2)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
FADD/Caspase 8 complex (CASP8-FADD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
Boldin et al., Cell 1996, Muzio et al., Cell 1996
Evidence: assay
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
NIK (MAP3K14)
(modification, activates)
Malinin et al., Nature 1997
-
NCI Pathway Database CD40/CD40L signaling:
cIAP1/cIAP2/TRAF2/TRAF3 complex (BIRC2-BIRC3-TRAF2-TRAF3)
→
NIK (MAP3K14)
(modification, activates)
Vallabhapurapu et al., Nat Immunol 2008, Zarnegar et al., Nat Immunol 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database CD40/CD40L signaling:
cIAP1/cIAP2 complex (BIRC2-BIRC3)
→
TRAF2 (TRAF2)
(modification, collaborate)
Zarnegar et al., Nat Immunol 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database CD40/CD40L signaling:
cIAP1/cIAP2 complex (BIRC2-BIRC3)
→
cIAP1/cIAP2/TRAF2 complex (BIRC2-BIRC3-TRAF2)
(modification, collaborate)
Zarnegar et al., Nat Immunol 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database CD40/CD40L signaling:
TRAF2 (TRAF2)
→
cIAP1/cIAP2/TRAF2 complex (BIRC2-BIRC3-TRAF2)
(modification, collaborate)
Zarnegar et al., Nat Immunol 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, activates)
Wiegmann et al., J Biol Chem 1999, Kolmakova et al., Arterioscler Thromb Vasc Biol 2004, Schwandner et al., J Biol Chem 1998
-
NCI Pathway Database Ceramide signaling pathway:
None
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, inhibits)
Wiegmann et al., J Biol Chem 1999, Kolmakova et al., Arterioscler Thromb Vasc Biol 2004, Schwandner et al., J Biol Chem 1998
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
Neutral sphingomyelinase II (SMPD3)
(modification, activates)
Wiegmann et al., J Biol Chem 1999, Kolmakova et al., Arterioscler Thromb Vasc Biol 2004, Schwandner et al., J Biol Chem 1998
-
NCI Pathway Database CD40/CD40L signaling:
cIAP1/cIAP2 complex (BIRC2-BIRC3)
→
CD40/CD40L (trimer)/TRAF2 (trimer)/cIAP1/cIAP2 complex (CD40LG-CD40-TRAF2-BIRC2-BIRC3)
(modification, collaborate)
Vallabhapurapu et al., Nat Immunol 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database CD40/CD40L signaling:
cIAP1/cIAP2 complex (BIRC2-BIRC3)
→
CD40/CD40L (trimer)/TRAF2 (trimer) complex (CD40LG-CD40-TRAF2)
(modification, collaborate)
Vallabhapurapu et al., Nat Immunol 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database CD40/CD40L signaling:
CD40/CD40L (trimer)/TRAF2 (trimer)/cIAP1/cIAP2 complex (CD40LG-CD40-TRAF2-BIRC2-BIRC3)
→
CD40/CD40L (trimer)/TRAF2 (trimer) complex (CD40LG-CD40-TRAF2)
(modification, collaborate)
Vallabhapurapu et al., Nat Immunol 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Ceramide signaling pathway:
Cathepsin D/ceramide complex (CTSD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, activates)
Heinrich et al., Cell Death Differ 2004
Evidence: assay
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, activates)
Testai et al., J Neurosci Res 2004, Takeshita et al., J Oral Sci 2005
Evidence: assay, physical interaction
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
Acid Sphingomyelinase (SMPD1)
(modification, activates)
Testai et al., J Neurosci Res 2004, Takeshita et al., J Oral Sci 2005
Evidence: assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
cIAP2 (BIRC3)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP1 (BIRC2)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP1 (BIRC2)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP2 (BIRC3)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP2 (BIRC3)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP2 (BIRC3)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP2 (BIRC3)
→
TRAF2 (TRAF2)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, activates)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
Caspase 8 (CASP8)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
→
Caspase 8 (tetramer) complex (CASP8)
(modification, inhibits)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Caspase Cascade in Apoptosis:
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD/PIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF-PIDD1)
→
Caspase 2 (CASP2)
(modification, activates)
-
NCI Pathway Database CD40/CD40L signaling:
TRAF3 (TRAF3)
→
cIAP1/cIAP2/TRAF2 complex (BIRC2-BIRC3-TRAF2)
(modification, collaborate)
Vallabhapurapu et al., Nat Immunol 2008, Zarnegar et al., Nat Immunol 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database CD40/CD40L signaling:
TRAF3 (TRAF3)
→
cIAP1/cIAP2/TRAF2/TRAF3 complex (BIRC2-BIRC3-TRAF2-TRAF3)
(modification, collaborate)
Vallabhapurapu et al., Nat Immunol 2008, Zarnegar et al., Nat Immunol 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database CD40/CD40L signaling:
cIAP1/cIAP2/TRAF2 complex (BIRC2-BIRC3-TRAF2)
→
cIAP1/cIAP2/TRAF2/TRAF3 complex (BIRC2-BIRC3-TRAF2-TRAF3)
(modification, collaborate)
Vallabhapurapu et al., Nat Immunol 2008, Zarnegar et al., Nat Immunol 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Ceramide signaling pathway:
cIAP2 (BIRC3)
→
TRAF2 (TRAF2)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
cIAP2 (BIRC3)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
TRAF2 (TRAF2)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
BAG4 (BAG4)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
RAIDD (CRADD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
TRADD (TRADD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
RIP (RIPK1)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
MADD (MADD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
TNFR1A/BAG4/TNF-alpha complex (TNFRSF1A-BAG4-TNF)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
Reactome Reaction:
BIRC3
→
TRAF2
(direct_complex)
-
WikiPathways Apoptosis:
BIRC2/BIRC3
→
TRAF3/TRAF1/TRAF2
(unknown)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
TRAF2
—
BIRC3
Li et al., Nature 2002
-
IRef Bind_translation Interaction:
TRAF2
—
BIRC3
(affinity chromatography technology)
Li et al., Nature 2002
-
IRef Biogrid Interaction:
TRAF2
—
BIRC3
(physical association, affinity chromatography technology)
Choudhary et al., J Biol Chem 2013*
-
IRef Biogrid Interaction:
TRAF2
—
BIRC3
(direct interaction, two hybrid)
Wang et al., Molecular systems biology 2011
-
IRef Biogrid Interaction:
TRAF2
—
BIRC3
(direct interaction, two hybrid)
Uren et al., Proc Natl Acad Sci U S A 1996*
-
IRef Biogrid Interaction:
TRAF2
—
BIRC3
(physical association, affinity chromatography technology)
Yoneda et al., J Biol Chem 2000*
-
IRef Biogrid Interaction:
TRAF2
—
BIRC3
(direct interaction, pull down)
Roy et al., EMBO J 1997
-
IRef Biogrid Interaction:
TRAF2
—
BIRC3
(physical association, affinity chromatography technology)
Behrends et al., Nature 2010
-
IRef Biogrid Interaction:
TRAF2
—
BIRC3
(direct interaction, pull down)
Li et al., Nature 2002
-
IRef Biogrid Interaction:
TRAF2
—
BIRC3
(direct interaction, pull down)
Samuel et al., J Biol Chem 2006*
-
IRef Biogrid Interaction:
TRAF2
—
BIRC3
(physical association, affinity chromatography technology)
Vince et al., J Biol Chem 2009*
-
IRef Biogrid Interaction:
TRAF2
—
BIRC3
(physical association, affinity chromatography technology)
Darding et al., Cell Death Differ 2011*
-
IRef Biogrid Interaction:
TRAF2
—
BIRC3
(physical association, affinity chromatography technology)
Zheng et al., Mol Cell 2010*
-
IRef Biogrid Interaction:
TRAF2
—
BIRC3
(direct interaction, pull down)
Zheng et al., Mol Cell 2010*
-
IRef Biogrid Interaction:
TRAF2
—
BIRC3
(association, x-ray crystallography)
Zheng et al., Mol Cell 2010*
-
IRef Biogrid Interaction:
TRAF2
—
BIRC3
(direct interaction, two hybrid)
Rothe et al., Cell 1995*
-
IRef Biogrid Interaction:
TRAF2
—
BIRC3
(physical association, affinity chromatography technology)
Zhang et al., J Biol Chem 2004
-
IRef Biogrid Interaction:
TRAF2
—
BIRC3
(physical association, affinity chromatography technology)
Varfolomeev et al., J Biol Chem 2006*
-
IRef Biogrid Interaction:
TRAF2
—
BIRC3
(physical association, affinity chromatography technology)
Goncharov et al., EMBO J 2013
-
IRef Hprd Interaction:
TRAF2
—
BIRC3
(two hybrid)
Li et al., Nature 2002, Samuel et al., J Biol Chem 2006*, Zarnegar et al., Nat Immunol 2008, Uren et al., Proc Natl Acad Sci U S A 1996*
-
IRef Hprd Interaction:
TRAF2
—
BIRC3
(in vitro)
Li et al., Nature 2002, Samuel et al., J Biol Chem 2006*, Zarnegar et al., Nat Immunol 2008, Uren et al., Proc Natl Acad Sci U S A 1996*
-
IRef Hprd Interaction:
Complex of 26 proteins
(in vivo)
Zarnegar et al., Nat Immunol 2008
-
IRef Hprd Interaction:
Complex of 82 proteins
(in vivo)
Matsuzawa et al., Science 2008
-
IRef Innatedb Interaction:
TRAF2
—
BIRC3
(unknown, -)
Zheng et al., Mol Cell 2010*
-
IRef Innatedb Interaction:
TRAF2
—
BIRC3
(unknown, -)
Varfolomeev et al., J Biol Chem 2006*
-
IRef Intact Interaction:
TRAF2
—
BIRC3
(physical association, pull down)
Samuel et al., J Biol Chem 2006*
-
IRef Intact Interaction:
TRAF2
—
BIRC3
(physical association, two hybrid)
Wang et al., Molecular systems biology 2011
-
IRef Intact Interaction:
Complex of 11 proteins
(physical association, anti tag coimmunoprecipitation)
Behrends et al., Nature 2010
-
IRef Intact Interaction:
Complex of BIRC3-TNF-BIRC2-TRAF2-TRADD
(association, anti tag coimmunoprecipitation)
Jennewein et al., Oncogene 2012
-
IRef Intact Interaction:
Complex of 21 proteins
(association, anti tag coimmunoprecipitation)
Goncharov et al., EMBO J 2013
-
IRef Intact Interaction:
Complex of BIRC3-DIABLO-TRAF2
(association, pull down)
Samuel et al., J Biol Chem 2006*
-
IRef Ophid Interaction:
TRAF2
—
BIRC3
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Noels et al., J Biol Chem 2007
(Lymphoma, B-Cell, Marginal Zone...) :
Finally, binding of
TRAF2 to BIR1
contributed to NF-kappaB activation by
API2.MALT1 , although additional mechanisms involving BIR1 mediated raft association are also important
Lucas et al., Oncogene 2007
:
Thus,
API2 moiety
mediated heterotypic oligomerization and
TRAF2 binding both contribute to maximal API2-MALT1 dependent NF-kappaB stimulation