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CCND1 — MYLIP

Text-mined interactions from Literome

Jiang et al., BMC cancer 2009 (Carcinoma...) : Of interest, we found that miR-503 not only suppressed the luciferase activity, but also suppressed the endogenous CCND1 both at protein and mRNA levels
Antonini et al., J Invest Dermatol 2010 : Concomitant downregulation of miR-34a and miR-34c substantially restored cell cycle progression and expression of cyclin D1 and Cdk4
Qin et al., Proc Natl Acad Sci U S A 2010 : In conclusion, we demonstrated that miR-19a plays an important role in the flow regulation of cyclin D1 expression
Chen et al., Am J Pathol 2010 (Melanoma...) : A luciferase reporter assay confirmed that miR-193b directly regulates CCND1 by binding to the 3'untranslated region of CCND1 mRNA ... These studies indicate that miR-193b represses cell proliferation and regulates CCND1 expression and suggest that dysregulation of miR-193b may play an important role in melanoma development
Hu et al., Int J Cancer 2011 (Adenocarcinoma...) : In addition, transient transfection of miR-34a inhibited c-Met and cyclin D1 expression and esophageal cancer cell proliferation, whereas miR-16-2 suppressed RAR-ß ( 2 ) expression and increased tumor cell proliferation
Lin et al., PloS one 2010 (Breast Neoplasms...) : Furthermore, upregulation of miR-96 in breast cancer cells resulted in modulation of their entry into the G1/S transitional phase, which was caused by downregulation of cyclin dependent kinase (CDK) inhibitors, p27 ( Kip1 ) and p21 ( Cip1 ), and upregulation of the cell-cycle regulator cyclin D1
Yu et al., BMC cancer 2012 (Breast Neoplasms) : MiRNA transfection and luciferase assay confirmed that bcl-2 was regulated by miR-16 and miR-143, cyclinD1 was modulated by miR-16
Hu et al., Acta Biochim Biophys Sin (Shanghai) 2012 (Carcinoma, Non-Small-Cell Lung...) : Moreover, miR-193b repressed the expressions of cyclin D1 and urokinase-type plasminogen activator in A549 cells
Zhang et al., Hepatology 2012 (Carcinoma, Hepatocellular...) : Up-regulated miR-155 resulted in nuclear accumulation of ß-catenin and a concomitant increase in cyclin D1 , c-myc, and survivin
Chen et al., Oncogene 2013 (Melanoma) : In previous studies, we demonstrated that miR-193b expression is reduced in melanoma relative to benign nevi, and also that miR-193b represses cyclin D1 and Mcl-1 expression
Dai et al., Placenta 2012 (Pre-Eclampsia) : Overexpression of miR-155 in HTR-8/SVneo cells reduced the level of cyclin D1 protein, decreased cell proliferation and invasion, and increased cell number at the G1 stage
Kim et al., Hepatology 2013 (Carcinoma, Hepatocellular...) : Bioinformatics analysis of target sites and ectopic expression in HCC cells showed that miR-125a-5p and miR-125b suppressed SIRT7 and cyclin D1 expression and induced p21WAF1/Cip1 dependent G1 cell cycle arrest
Maki et al., Anticancer Res 2012 (Mesothelioma...) : miR-34b/c inhibited expression of cyclin-D1 , cyclin dependent kinase 4/6, B-cell lymphoma-2 (BCL-2) and increased cleaved poly ( ADP-ribose ) polymerase ( cPARP ) and cleaved caspase-3 after irradiation
Rio-Machin et al., Leukemia 2013 (Multiple Myeloma...) : We found that target genes of the most differentially expressed miRNAs are directly involved in the pathogenesis of MM ; specifically, the inhibition of hsa-miR-425 , hsa-miR-152 and hsa-miR-24, which are all downregulated in h-MM, leads to the overexpression of CCND1 , TACC3, MAFB, FGFR3 and MYC, which are the also the oncogenes upregulated by the most frequent IgH chromosomal translocations occurring in nh-MM. Importantly, we showed that the downregulation of these specific miRNAs and the upregulation of their targets also occur simultaneously in primary cases of h-MM
Fu et al., Zhonghua Gan Zang Bing Za Zhi 2012 (Carcinoma, Hepatocellular...) : The protein levels of cyclinD1 , cyclinG1, and E2F1 were significantly reduced by both miR-338-3p and miR-551b ( P less than 0.001 )
Li et al., Blood 2013 (Leukemia, Myeloid, Acute) : Suppression of miR-193a expands the oncogenic activity of the fusion protein AML-ETO, because miR-193a represses the expression of multiple target genes, such as AML1/ETO, DNMT3a, HDAC3, KIT, CCND1 , and MDM2 directly, and increases PTEN indirectly ... Suppression of miR-193a expands the oncogenic activity of the fusion protein AML-ETO, because miR-193a represses the expression of multiple target genes, such as AML1/ETO, DNMT3a, HDAC3, KIT, CCND1 , and MDM2 directly, and increases PTEN indirectly
Lei et al., PloS one 2012 (Uterine Cervical Neoplasms) : Further, the overexpression of miR155 increased TP53 expression but reduced SMAD2, and CCND1 expression levels
Hu et al., Biomaterials 2013 (Pancreatic Neoplasms) : The up-regulation of miR-34a remarkably induced cell cycle arrest and apoptosis, suppressed the tumor cell migration and inhibited the target gene expressions such as E2F3, Bcl-2, c-myc and cyclin D1
Poudel et al., Biochem Biophys Res Commun 2013 (Neoplasms) : The transient transfection of pre-miR-30C resulted in greater than 70 % growth inhibition in PC-3 cells and provided strong evidence that miR-30C selectively suppresses the expression of cyclin D1 and D2, but not cyclin D3
Zheng et al., PloS one 2013 (Neoplasm Invasiveness...) : Ectopic expression or knockdown of miR-9 resulted in responsively altered expression of cyclin D1 , Ets1 and their downstream targets phosphorylated retinoblastoma and matrix metalloproteinase 9 in cultured gastric cancer cell lines SGC-7901 and AGS ... Restoration of miR-9 mediated down-regulation of cyclin D1 and Ets1 by transient transfection, rescued the cancer cells from decrease in proliferation, migration and invasion
Li et al., Cardiovasc Res 2013 : Furthermore, we identified the orphan nuclear receptor NOR1 as a downstream target gene product of miR-638 and down-regulation of NOR1 is critical for miR-638 mediated inhibitory effects on PDGF induced cyclin D1 expression, cell proliferation, and migration in human aortic SMCs
Shan et al., International journal of molecular sciences 2013 : In addition, miR-590-5P expression suppressed the expression of Wnt5a, cMyc and cyclin D1 , and increased the phosphorylation of ß-catenin and expression of Caspase 3, which may contribute to the inhibitory effect of miR-590-5P on cell growth
Guo et al., Oncol Rep 2013 : Furthermore, the overexpression of miR-708 reduced the expression of Akt1, CCND1 , MMP2, EZH2, Parp-1 and Bcl2 in A172 and T98G cells
Jiang et al., Asian Pac J Cancer Prev 2013 (Urinary Bladder Neoplasms) : At the molecular level, our results further revealed that cyclin D1 expression was negatively regulated by miR-16