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CSK — PRKAR2B

Pathways - manually collected, often from reviews:

• BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: PKA complex (PRKACB-PRKACG-PRKAR1A-PRKAR1B-PRKAR2A-PRKAR2B) → CSK (modification, activates)

Text-mined interactions from Literome

Yaqub et al., Biochem J 2003 : In the present study, we investigate the mechanism for the protein kinase A (PKA) mediated activation of C-terminal Src kinase (Csk) ... This suggests that an overall structural domain organization and interaction between the kinase and SH3 domains are important for the activity of Csk and its regulation by PKA
Taskén et al., Biochem Soc Trans 2006 : cAMP inhibits Src-family kinase signalling by PKA ( protein kinase A ) -mediated phosphorylation and activation of Csk ( C-terminal Src kinase )
Ruppelt et al., J Immunol 2007 : cAMP negatively regulates T cell immune responses by activation of type I protein kinase A (PKA) , which in turn phosphorylates and activates C-terminal Src kinase (Csk) in T cell lipid rafts