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BCL2 — IL2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Kolenko et al., Blood 1999
(Second Messenger Systems) :
In contrast,
IL-2 dependent induction of
Bcl-2 was unaffected
Demir et al., Anticancer Res 1999
(Bone Neoplasms...) :
We designed a prospective pilot study to evaluate in vivo
effects of low dose
IL-2 and IFN-alpha combination on expression of
Bcl-2 , FAS ( Apo-1/CD 95 ), Fas Ligand, IL-2 receptor ( CD25 ), and HLA-DR on peripheral lymphocytes in patients with advanced renal cell carcinoma
Graninger et al., Cell Death Differ 2000
(Lupus Erythematosus, Systemic) :
IL-2 , IL-4, IL-7 and IL-15
led to a significant increase in
Bcl-2 and a reduction in cell death rates, which was even more pronounced in SLE
David et al., AIDS 2002
(HIV Infections) :
Since
interleukin-2 (IL-2) induces
Bcl-2 and participates in the control of lymphocyte apoptosis, we also investigated the IL-2/IL-2 receptor (IL-2R) system in these CD4-LR patients
Ilangumaran et al., J Immunol 2003
(Lymphoproliferative Disorders) :
However, IL-15 and
IL-2 induce comparable levels of
Bcl-2 and Bcl-x ( L ) in SOCS1-deficient and SOCS1-sufficient CD8+ T cells, suggesting that cytokine receptor signals required for inducing proliferation and cell survival signals are not identical
Verschelde et al., Cell Death Differ 2003
:
Activation of CD4 ( + ) or CD8 ( + ) T cells by antigenic peptides induced an early but transient IL-2 independent expression of A1 and Bcl-xl mRNA and proteins, whereas expression of
Bcl-2 was delayed and
required IL-2
Crawley et al., Int Immunol 2009
:
We show here that ( i ) memory cells ( CD127+CD45RA- ) divide frequently in response to either IL-2, -4 or -15 ; ( ii ) IL-2 and -15 enhance cell division in effector-memory-like cells ( CD127-CD45RA+ ) while IL-4 enhances the cell division of effector cells ( CD127-CD45RA- ) ; ( iii ) CD8+CD127+ T cells are more sensitive to the anti-apoptotic effects of IL-2 or IL-15 than CD8+CD127- T cells and ( iv ) CD8+CD127+ T cell produce more
Bcl-2 in
response to
IL-2 or IL-15 compared with CD8+CD127- T cells
White et al., Crit Care 2011
(Bacteremia...) :
IL-7 protein levels were similar in all groups.In cultured PBLs, IFN-? gene expression was decreased in response to LPS and increased in response to CD3ab with sepsis : IL-7 gene expression increased in response to LPS in controls and to CD3ab with sepsis ;
Bcl-2 gene expression decreased in
response to combined CD3ab and
IL-2 with sepsis
Nuñez et al., J Immunol 1990
:
Overexpressed
Bcl-2 resulted in no long term
IL-2 , IL-3, or IL-6 independent clones, indicating that Bcl-2 could not spare the need for a specific ligand-receptor interaction
Broome et al., Immunology 1995
:
These data document the
IL-2 dependent expression of
Bcl-2 in activated T cells, confirm the ability of deregulated bcl-2 to inhibit the onset of apoptosis after IL-2 withdrawal, but suggest that, after IL-2 withdrawal, a drop in Bcl-2 levels relative to total protein levels does not precede apoptosis
Linette et al., Proc Natl Acad Sci U S A 1996
:
However, the transcription and synthesis of
interleukin 2 and other delayed early cytokines were markedly
attenuated by
BCL-2
Gómez et al., Eur J Immunol 1997
:
IL-2 , but not IL-4,
induces Bcl-2 expression through RhoA activation which is inhibited by the specific Rho family inhibitor, Clostridium difficile Toxin B, as well as by a dominant negative RhoA mutant