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ATM — TP53

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TP53 → ATM (directlyIncreases, TP53 Activity)
  Evidence: 11875057;10446957
• OpenBEL Selventa BEL large corpus: TP53 → ATM (directlyIncreases, TP53 Activity) Fabbro et al., J Biol Chem 2004*
  Evidence: In this report, we utilized small interfering RNA to deplete BRCA1 and BARD1 to demonstrate that the BRCA1-BARD1 complex is required for ATM/ATR (ataxia-telangiectasia-mutated/ATM and Rad3-related)-mediated phosphorylation of p53(Ser-15) following IR- and UV radiation-induced DNA damage.
• OpenBEL Selventa BEL large corpus: TP53 → ATM (directlyIncreases, TP53 Activity)
  Evidence: ATM phosphorylates P53 at Ser15
• OpenBEL Selventa BEL large corpus: TP53 → ATM (directlyIncreases, TP53 Activity) Buscemi et al., Oncogene 2004*
  Evidence: We show that doses of gamma-radiation (IR) as low as 0.25 Gy, which generate vast numbers of SSBs but only a few DSBs per cell (<8), promptly activate ATM kinase and induce the phosphorylation of the ATM substrates p53-Ser15, Nbs1-Ser343 and Chk2-Thr68.
• BioCarta atm signaling pathway: ATR/ATRIP/ATM complex (ATR-TREX1-ATM) → p53/MDM2 complex (TP53-MDM2) (modification, activates)
  
• BioCarta atm signaling pathway: ATR/ATRIP/ATM complex (ATR-TREX1-ATM) → p53 (TP53) (modification, activates)
• BioCarta cell cycle: g2/m checkpoint: p53/MDM2 complex (TP53-MDM2) → ATM (modification, collaborate)
• KEGG Cell cycle: ATM/ATR → TP53 (protein-protein, phosphorylation)
• KEGG p53 signaling pathway: ATM → TP53 (protein-protein, activation)
• KEGG Apoptosis: ATM → TP53 (protein-protein, activation)
• NCI Pathway Database p53 pathway: ATM (ATM) → p53 (TP53) (modification, activates) Banin et al., Science 1998*, Canman et al., Science 1998*
  Evidence: mutant phenotype, assay
• Reactome Reaction: TP53 → ATM (reaction) Banin et al., Science 1998*, Canman et al., Science 1998*, Khanna et al., Nat Genet 1998*
• WikiPathways Pathways Affected in Adenoid Cystic Carcinoma: ATM → TP53 (activation)
• WikiPathways Signaling Pathways in Glioblastoma: ATM → TP53 (mim-stimulation)
• WikiPathways miRNA Regulation of DNA Damage Response: ATM → TP53 (activation) Zhou et al., Nat Rev Cancer 2004*
• WikiPathways Cell Cycle: ATM/ATR → TP53 (activation) Canman et al., Science 1998*
• WikiPathways ATM Signaling Pathway: ATM → TP53 (mim-stimulation)
• WikiPathways DNA Damage Response (only ATM dependent): ATM → TP53 (activation)
• WikiPathways DNA Damage Response: ATM → TP53 (activation) Zhou et al., Nat Rev Cancer 2004*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: TP53 — ATM (experimental interaction detection) Bhoumik et al., Mol Cell 2005*
• IRef Bind_translation Interaction: ATM — TP53 (affinity chromatography technology) Lee et al., Science 2004
• IRef Bind_translation Interaction: ATM — TP53 (experimental interaction detection) Lee et al., Science 2004
• IRef Bind_translation Interaction: ATM — TP53 (experimental interaction detection) Brumbaugh et al., Mol Cell 2004*
• IRef Bind_translation Interaction: ATM — TP53 (experimental interaction detection) Lee et al., Science 2005
• IRef Biogrid Interaction: ATM — TP53 (direct interaction, enzymatic study) Lee et al., Science 2005
• IRef Biogrid Interaction: ATM — TP53 (direct interaction, enzymatic study) Lee et al., Science 2004
• IRef Biogrid Interaction: ATM — TP53 (direct interaction, enzymatic study) Khanna et al., Nat Genet 1998*
• IRef Biogrid Interaction: ATM — TP53 (direct interaction, enzymatic study) Lin et al., Genes Dev 2001*
• IRef Biogrid Interaction: ATM — TP53 (direct interaction, enzymatic study) Ling et al., J Biol Chem 2011*
• IRef Biogrid Interaction: ATM — TP53 (direct interaction, enzymatic study) Hunt et al., Cancer Res 2007*
• IRef Biogrid Interaction: ATM — TP53 (direct interaction, enzymatic study) Taira et al., J Biol Chem 2010*
• IRef Biogrid Interaction: ATM — TP53 (direct interaction, enzymatic study) Zhou et al., J Biol Chem 2000*
• IRef Biogrid Interaction: ATM — TP53 (direct interaction, pull down) Lee et al., Science 2004
• IRef Biogrid Interaction: ATM — TP53 (direct interaction, pull down) Khanna et al., Nat Genet 1998*
• IRef Biogrid Interaction: ATM — TP53 (direct interaction, enzymatic study) Yoshiyama et al., EMBO Rep 2013*
• IRef Biogrid Interaction: ATM — TP53 (direct interaction, enzymatic study) Chan et al., J Biol Chem 2000*
• IRef Biogrid Interaction: ATM — TP53 (direct interaction, pull down) Fabbro et al., J Biol Chem 2004*
• IRef Biogrid Interaction: ATM — TP53 (direct interaction, pull down) Kang et al., Mol Cell Biol 2005*
• IRef Biogrid Interaction: ATM — TP53 (direct interaction, unspecified method) Kim et al., J Biol Chem 1999
• IRef Dip Interaction: Complex of RRM2B-ATM-TP53 (anti bait coimmunoprecipitation) Chang et al., Proc Natl Acad Sci U S A 2008
• IRef Hprd Interaction: TP53 — ATM (in vivo) Shieh et al., Genes Dev 2000*, Xie et al., J Biol Chem 2001, Latonen et al., Oncogene 2001*, Saito et al., J Biol Chem 2002*, Kozlov et al., EMBO J 2006, Bruno et al., Cancer Cell 2006*, Giaccia et al., Genes Dev 1998*, Khanna et al., Nat Genet 1998*
• IRef Hprd Interaction: TP53 — ATM (in vitro) Shieh et al., Genes Dev 2000*, Xie et al., J Biol Chem 2001, Latonen et al., Oncogene 2001*, Saito et al., J Biol Chem 2002*, Kozlov et al., EMBO J 2006, Bruno et al., Cancer Cell 2006*, Giaccia et al., Genes Dev 1998*, Khanna et al., Nat Genet 1998*
• IRef Intact Interaction: TP53 — ATM (phosphorylation reaction, experimental interaction detection) Delia et al., Br J Cancer 2000*
• IRef Ophid Interaction: TP53 — ATM (aggregation, confirmational text mining) Khanna et al., Nat Genet 1998*
• IRef Ophid Interaction: TP53 — ATM (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Taylor et al., Oncogene 2001 : Chk1, Chk2, Atm and Atr also contribute to the activation of p53 in response to genotoxic stress and therefore play multiple roles
Silins et al., Carcinogenesis 2001 (Liver Neoplasms...) : An inhibitor of DNA dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) , wortmannin, blocked the DEN induced p53 response in non-EAF hepatocytes
Das et al., Am J Physiol Lung Cell Mol Physiol 2004 (Adenocarcinoma...) : Although H2O2 and other peroxides have been shown to induce ataxia telangiectasia mutated (ATM) dependent p53 phosphorylation in response to DNA damage, the signal transduction mechanisms in response to hyperoxia are currently unknown
Rogoff et al., Mol Cell Biol 2004 : Both Atm and Nbs1 contribute to Chk2 activation and p53 phosphorylation following deregulation of normal Rb growth control
Yoon et al., Mol Cell Biol 2004 : UVB induced C/EBPalpha was accompanied by an increase in p53 protein and caffeine, an inhibitor of ataxia-telangiectasia mutated kinase, and ataxia-telangiectasia mutated and Rad3 related kinase inhibited UVB induced increases in both C/EBPalpha and p53
Lozano et al., J Pathol 2005 (Disease Models, Animal...) : Additionally, upstream regulators of p53 activity, such as p19(Arf) and Atm , are themselves critical tumour modifiers/suppressors
Al Rashid et al., Cancer Res 2005 : Despite a clear link between ataxia-telangiectasia mutated (ATM) dependent phosphorylation of p53 and cell cycle checkpoint control, the intracellular biology and subcellular localization of p53 phosphoforms during the initial sensing of DNA damage is poorly understood
Song et al., Nat Cell Biol 2007 (Cell Transformation, Neoplastic...) : These acquired oncogenic properties of mutant p53 could be explained by the findings that these p53 mutants interact with the nuclease Mre11 and suppress the binding of the Mre11-Rad50-NBS1 (MRN) complex to DNA double stranded breaks ( DSBs ), leading to impaired Ataxia-telangiectasia mutated (ATM) activation
Gurley et al., Mol Cancer Res 2007 : Ataxia-telangiectasia mutated is not required for p53 induction and apoptosis in irradiated epithelial tissues ... Although Atm can regulate p53 , it is not known if this Atm function varies between tissues
Nalapareddy et al., EMBO Rep 2010 : Telomere shortening limits the proliferation of primary human fibroblasts by the induction of senescence, which is mediated by ataxia telangiectasia mutated dependent activation of p53
Yuan et al., J Biol Chem 2010 : HDAC9 deacetylates ATDC, alters the ability of ATDC to associate with p53 , and consequently inhibits the cell proliferation promoting activity of ATDC
Santoro et al., Oncogene 2012 : Melatonin induced p53 phosphorylation at Ser-15 residue does not require ataxia telangiectasia mutated activity, whereas it is severely impaired upon chemical inhibition of p38 mitogen activated protein kinase activity
Zhang et al., PloS one 2013 : We found that 5-Iodotubercidin could cause DNA damage, verified by induction of DNA breaks and nuclear foci positive for ?H2AX and TopBP1, activation of Atm and Chk2, and S15 phosphorylation and up-regulation of p53
Wang et al., International journal of biomedical science : IJBS 2007 : DNA damage response is triggered by double stranded DNA breaks, single stranded DNA breaks as well as other types of lesions, which recruit and activate Ser/Thr kinases such as Atm to the damaged sites, where Atm activates p53 to promote apoptosis, cell cycle arrest, and DNA repair
Barlow et al., Nat Genet 1997 (Ataxia Telangiectasia...) : Thus, Atm deficiency results in lack of p53 induction by IR, but only selective disruption of p53 dependent functions