Hummer et al., J Virol 2001
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We demonstrate that the interferon stimulated gene ISG15 is induced by p53 and that p53 is required for optimal gene induction by double stranded RNA ( dsRNA ), but not interferon
Liu et al., J Interferon Cytokine Res 2004
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ISG15 is induced by IFN, microbial challenge, and p53 , suggesting that it represents a genetic response that is shared among diverse stress stimuli