Gene interactions and pathways from curated databases and text-mining

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CDKN1A — CKAP4

Text-mined interactions from Literome

Zeng et al., EMBO J 2002 : Over expression of wild-type, but not deletion mutant, SSRP1 remarkably enhanced p63gamma dependent luciferase activity, G1 arrest, apoptosis and expression of endogenous PIG3, p21 ( Waf1/cip1 ) and MDM2 in human p53-deficient lung carcinoma H1299 cells and mouse embryonic fibroblasts
MacPartlin et al., J Biol Chem 2005 : These results suggest that p300 regulates p63 dependent transcription of p21
DeYoung et al., Cancer Res 2006 (Carcinoma, Squamous Cell...) : In normal primary human keratinocytes, we find that inhibition of endogenous p63 by RNA interference ( RNAi ) induces p21 ( CIP1 ) expression, inhibits cell cycle progression, and ultimately promotes cellular senescence
Mitchell et al., Cell death & disease 2010 : As p21, a transcriptional target of the p53 family, is necessary for maintaining G2/M arrest, we analyzed the roles of p53 and p63 in modulating IGF1 stimulated p21 expression