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CDKN1A — IL1A
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Osawa et al., J Biochem 2000
:
IL-1 induces expression of
p21 ( WAF1 ) independently of p53 in high-passage human embryonic fibroblasts WI38 ... We tested the
effect of
IL-1 on the expression of
p21 ( WAF1 ) in human embryonic fibroblasts WI38 ... These results suggest that the
induction of
p21 ( WAF1 ) by
IL-1 occurs at the transcriptional level, but p53 function is not required in these cells ... Further studies found that IL-1 did not cause cell-cycle arrest, and the overexpression of p21 ( WAF1 ) resulted in only a slight delay of cell growth, while the level of
p21 ( WAF1 ) coprecipitated with cyclin dependent kinase-2 (Cdk2) was
increased by
IL-1 ... Thus,
IL-1 mediates
p21 ( WAF1 ) induction through a p53 independent pathway ( s ) in high-passage WI38 cells, but the cell cycle is regulated independently of p21 ( WAF1 )
Arakawa et al., Biochem Biophys Res Commun 2010
(Melanoma) :
The degradation of
p21 was
inhibited by
IL-1 , however the ubiquitination level of p21 was not affected ... These results suggest that
IL-1 induced ERK1/2 activation
leads to the up-regulation of
p21 by inhibiting degradation via ubiquitin independent pathway in human melanoma cells A375
Qin et al., Mol Cancer Res 2011
(Disease Progression...) :
Downregulation of
IL-1a , IL-1ß, or MyD88 substantially
increased p21 and p53 levels
Clérigues et al., Clin Sci (Lond) 2012
(Bone Resorption...) :
We have found that HO-1 induction could regulate senescence markers in the
presence of
IL-1ß and significantly affected telomerase expression, as well as ß-galactosidase activity and hTERT ( human telomerase reverse transcriptase ) and
p21 expression in chondrocytes
Nalca et al., J Biol Chem 1998
:
Studies aimed at testing the role of p21/WAF1 in IL-1 action indicated that
IL-1 induced
p21/WAF1 expression independently of the p53 status of the cells