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HSF1 — RELA
Text-mined interactions from Literome
Tacchini et al., J Cell Physiol 1999
(Reperfusion Injury) :
3 ) Reperfusion, which is known to further increase the binding of
HSF and to
induce NFkappaB binding, abrogates or decreases the binding of HIF-1 and AP-1, stimulated by ischemia, and activates the binding of ATF/CREB
Ianaro et al., FEBS Lett 2001
(Disease Models, Animal...) :
In conclusion, we demonstrate that cyclopentenone prostaglandins may act as anti-inflammatory mediators by inducing in inflammatory cells
HSF1 dependent hsp72 expression and
NF-kappaB inhibition, two crucial events for the remission of inflammation
Hamilton et al., J Mol Cell Cardiol 2004
(Anoxia) :
Electromobility shift assays revealed activation of
HSF1 by 2 to 3 hr, and
NF kappa B activation by 15 min. HSP72 induction via HSF1 activation was confirmed using transcription factor decoys containing the heat shock element, which prevented the estrogen related HSP72 induction
Hamilton et al., Arterioscler Thromb Vasc Biol 2004
:
NF-kappaB mediates the early increase in HSP72, suggesting that estrogen activates NF-kappaB via a nongenomic, receptor dependent mechanism, and this
leads to activation of
HSF-1
Mandrekar et al., J Leukoc Biol 2008
(Inflammation) :
Heat shock proteins ( hsps ) and the
heat shock transcription factor-1 ( HSF-1 ) induced by oxidative stress
regulate NF-kappaB activation and TNF-alpha gene expression in monocytes and macrophages
Song et al., J Crit Care 2008
:
Endotoxin tolerance and HS appear to share a common immune suppressive effect, possibly through
HSF-1 mediated competitive inhibition of
NF-kappaB nuclear binding
Wu et al., Gene 2013
:
Although
HSF1 did n't significantly
inhibit the intracellular activation of
RelA induced by TNFa at an early stage, HSF1 decreased the levels of RelA and the translocation of RelA in the cytoplasm and cell nucleus at late stage
Jornot et al., FEBS Lett 1997
:
Human endothelial cells exposed to H2O2 showed reduced CREP DNA binding activity, enhanced
HSF activation , and no induction of
NFkappaB binding activity ... In contrast, cells exposed to TNF alpha showed enhanced CREP binding activity,
activation of
NFkappaB and no induction of
HSE-HSF complex
Scheuren et al., Br J Pharmacol 1998
:
The effect of ibuprofen was specific because, at concentrations up to 10 mM, ibuprofen did not affect the
heat shock transcription factor ( HSF ) and the
activation of
NF-kappaB by prostaglandin E2 ( PGE2 )