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CPD — MYC

Text-mined interactions from Literome

Ge et al., J Hepatol 2004 (Carcinoma, Hepatocellular...) : The aim was to investigate whether c-Myc was involved in Cpd 5-induced cell growth inhibition ... Cpd 5 was found to inhibit c-Myc protein expression and induce c-Myc phosphorylation in Hep 3B cells ... The phosphorylation of c-Myc was induced by both Cpd 5-mediated persistent extracellular signal regulated kinase ( ERK ) phosphorylation and Cpd 5 increased glycogen synthase kinase-3 ( GSK-3 ) activity ... When using GSK-3 inhibitor, SB216763, c-Myc phosphorylation was significantly decreased and c-Myc levels were restored in Cpd 5 treated cells, suggesting that Cpd 5-mediated increase of GSK-3 activity enhanced c-Myc degradation and resulted in reduction of c-Myc levels ... The results suggest that Cpd 5-mediated c-Myc phosphorylation resulted in enhanced c-Myc protein degradation and reduced c-Myc protein levels, which may contribute to cell growth inhibition by Cpd 5
Wang et al., J Cell Physiol 2006 (Carcinoma, Hepatocellular...) : Furthermore, Cpd 5 inhibited c-Myc transcriptional activity and DNA binding ability, and this inhibition was antagonized by ERK kinase ( MEK ) inhibitor U-0126, implying that the ERK pathway was involved in regulating c-Myc expression ... Since the participation of c-Myc protein in transcription requires its dimerization with Max protein, we examined the Myc-Max association in Cpd 5-treated cells and found that Cpd 5 suppressed Myc-Max dimerization ... We found that phospho-Myc induced by Cpd 5 had lost its ability to bind to the c-myc promoter, whereas MEK inhibitor U-0126 antagonized this inhibitory effect