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ANGPT2 — POLDIP2
Text-mined interactions from Literome
Deguchi et al., Circ Res 1999
:
In newborn rat VSMCs,
Ang II activates extracellular signal regulated protein kinase ( ERK ), c-Jun N-terminal protein kinase (JNK), and
p38 mitogen activated protein kinase
Tsiani et al., Am J Physiol Endocrinol Metab 2002
:
In HG,
activation of
p38 by ET-1,
ANG II , or PDGF was enhanced compared with NG and was protein kinase C ( PKC ) independent
El Bekay et al., Blood 2003
(Calcium Signaling...) :
Furthermore,
Ang II induced a robust phosphorylation of
p38MAPK , ERK1/2, and JNK1/2 ( particularly JNK2 ), which was hindered by inhibitors of NADPH oxidase, tyrosine kinases, and ROS scavengers
Li et al., Circulation 2004
(MAP Kinase Signaling System) :
In WT aortae,
Ang II increased NADPH dependent O2- production ( 2.5+/-0.5-fold ; P < 0.05 ), impaired relaxation to acetylcholine ( maximum 60+/-6 % versus 80+/-3 % ; P < 0.05 ), and
increased ERK1/2,
p38MAPK , and JNK phosphorylation ( P < 0.05 )
Li et al., Free Radic Biol Med 2005
(Cardiomegaly) :
Ang II induced the phosphorylation of PKC, Erk1/2, JNK, and
p38 in cardiomyocytes and such phosphorylation was
inhibited by ISO
Su et al., Kidney Int 2006
:
Ang II ( 5 min, 10 ( -7 ) M )
stimulated phosphorylation of the three MAPK (
p38 , extracellular signal related kinase ( ERK 1/2 ), and c-Jun N-terminal kinase (JNK) )
Liu et al., Circ Res 2006
(Body Weight...) :
In addition,
Ang II-induced AT(1)R expression was
blocked by losartan and a JNK inhibitor, but not by extracellular signal regulated kinase or
p38 MAP kinase inhibitors in a neuronal cell culture
Pham et al., J Cell Physiol 2008
:
Ang II and EGF
induced transient phosphorylation of ERK,
p38 ( MAPK ) and CREB
Nie et al., Mol Immunol 2009
:
Both Ang- ( 1-7 ) and
Ang II had no effect on
p38 and c-Jun N-terminal kinase (JNK) phosphorylation
Lin et al., PloS one 2012
(Cardiomegaly) :
Angeli 's salt also suppresses
Ang II induction of key triggers of the cardiomyocyte hypertrophic response, including NADPH oxidase ( on both Nox2 expression and superoxide generation ), as well as
p38 mitogen activated protein kinase ( p38MAPK )