Saetre et al., Shock 2001
(Shock, Septic...) :
GAS caused increases in tissue iNOS activity ( 9 h ), in serum nitrite/nitrate ( 9-24 h ), and in intracellular leukocyte ROS levels ( 3-6 h )
Gao et al., J Biol Chem 1997
:
An interferon-gamma activated site ( GAS ) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharide ... These data collectively support the conclusion that binding of Stat1 alpha to the iNOS promoter 's GAS is required for optimal induction of the iNOS gene by IFN-gamma and LPS
Darville et al., Diabetologia 1998
:
Site-mutation analysis showed that both the distal and proximal NF-kappaB and GAS are necessary for IL-1beta induced iNOS expression in RINm5F cells