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PDCD4 — TGFB1
Text-mined interactions from Literome
Mazars et al., Oncogene 2000
:
The
transforming growth factor beta ( TGF-beta ) plays an important role in constraining cellular proliferation, but it is also a potent
inducer of
programmed cell death or apoptosis
Ottaviani et al., Prog Mol Subcell Biol 2004
:
PDGF-AB and
TGF-beta1 partially
inhibit the induced
programmed cell death in an insect cell line, and the survival effect is mediated by the activation of phosphatidylinositol 3-kinase, PKA and PKC
de Luján Alvarez et al., Hepatology 2004
(Liver Neoplasms, Experimental...) :
The aim of this study was to determine if
transforming growth factor beta1 ( TGF-beta1 ) was
involved in the
programmed cell death on the foci
Zhang et al., Oncogene 2006
(Carcinoma, Hepatocellular...) :
Transfection of Smad7, a known antagonist to TGF-beta1 signaling, protected cells from TGF-beta1 mediated apoptosis and suppressed
TGF-beta1 induced
PDCD4 expression
Quiroga et al., Biochem Pharmacol 2007
(Precancerous Conditions) :
TGF-beta(1) , in turn, reduces hepatocytes antioxidant defenses and
induces programmed cell death
Quiroga et al., Growth Factors 2009
(Liver Neoplasms...) :
This
TGF-beta(1) , alters antioxidant defences and
induces programmed cell death
Nakashima et al., Biochim Biophys Acta 2010
:
Furthermore, siRNA mediated knockdown of PKCdelta and epsilon, but not PKCalpha, augmented the
TGF-beta1 stimulated
PDCD4 protein expression
Sookoian et al., Atherosclerosis 2011
(Anoxia...) :
Systems biology analysis revealed highly scored pathways involved in the regulation of
programmed cell death , angiogenesis, and immune system, in which
TGFB1 was mostly
involved
Sachsenmeier et al., J Biol Chem 1996
:
We have investigated the
role of
transforming growth factor-beta 1 ( TGF-beta 1 ) in suspension induced
programmed cell death of cultured human keratinocytes
Tanaka et al., Cancer Res 1996
(Carcinoma, Hepatocellular...) :
Although parental Hep3B cells were sensitive to apoptosis, the Hep3B-IRS-I transfected cells acquired resistance to
TGF-beta1 induced
programmed cell death
Maccarrone et al., Eur J Biochem 1996
(Leukemia, Erythroblastic, Acute) :
Membrane modifications in human erythroleukemia K562 cells during
induction of
programmed cell death by
transforming growth factor beta 1 or cisplatin
Taetle et al., Clin Cancer Res 1996
(Multiple Myeloma) :
Using previously studied cell line models, flow cytometry detected
programmed cell death induced by
transforming growth factor beta1 in leukemia cells and by anti-growth factor receptor antibody treatment of IL-6 dependent myeloma cells, treatments which caused only modest increases in the percentage of cells undergoing morphological apoptosis and increased internucleosomal DNA degradation