Cleator et al., Blood 2006
(Calcium Signaling) :
PAR2-AP failed to increase global cAMP levels ; however, inhibition of protein kinase A led to a significant attenuation of PAR2-AP mediated release of VWF Tull et al., PloS one 2012
:
However, knockdown of PARs by small interfering RNA showed that neither PAR1 nor PAR2 activation caused PR3 or elastase mediated vWF release
Storck et al., Thromb Res 1996
:
Both, the activation of the thrombin receptor with thrombin or SFLLRN and the activation of the PAR-2 with trypsin or SLIGRL induced intracellular calcium mobilisation and a subsequent release of von Willebrand factor (vWf) from Weibel-Palade bodies