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EGF — TRH

Text-mined interactions from Literome

Wang et al., Mol Endocrinol 2000 (Pituitary Neoplasms) : TRH induced EGF receptor phosphorylation was found to lead to the recruitment of the adapter proteins Grb2 and Shc
Hinkle et al., Endocrinology 1991 : The effects of EGF on TRH receptors were reversible
Spuch et al., Endocrine 2006 : Both FGF-2 ( 2 x 10 ( -11 ) M ) and EGF ( 6.6 x 10 ( -9 ) M ) significantly increase ( > 30 % and > 120 %, respectively ) the PRL levels in response to TRH ( 10 ( -6 ), 10 ( -5 ) M )
Kaji et al., J Biol Chem 1988 (Pituitary Neoplasms) : The present study examined the effect of TRH on EGF binding to intact GH4C1 rat pituitary tumor cells to test whether TRH activates protein kinase C. Cells were incubated with TRH at 37 degrees C and specific 125I-EGF binding was then measured at 4 degrees C. 125I-EGF binding was decreased by a 10-min treatment with 0.1-100 nM TRH to 30-40 % of control in a dose dependent manner ... GH4C1 cells were incubated with 500 nM TPA for 24 h in order to down-regulate protein kinase C. Protein kinase C depletion was confirmed by immunoblots and the effects of TRH and TPA on 125I-EGF binding were tested
Monden et al., J Mol Endocrinol 1995 : To gain insight into the mechanism underlying the epidermal growth factor (EGF) induced changes in responsiveness to TRH and in the numbers of TRH receptors (TRH-Rs) in the pituitary, we investigated the transcriptional regulation by EGF of the TRH-R gene in GH4C1 cells ... Northern blot analyses and binding studies revealed that EGF reduced both TRH binding and TRH-R mRNA levels in a dose- and time dependent manner, while no significant changes were observed in beta-actin mRNA levels
Ren et al., Endocrinology 1998 : Regulation of the expression of the prepro-TRH ( ppTRH ) gene by epidermal growth factor (EGF) was investigated