Gene interactions and pathways from curated databases and text-mining

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CAV2 — IRF6

Text-mined interactions from Literome

Lei et al., Infect Immun 2000 : In RAW264.7 cells, both caveolin-1 mRNA and protein levels are down-regulated by LPS ... In TG-elicited C3HeB/FeJ peritoneal macrophages, in contrast, expression of both caveolin-1 protein and mRNA is up-regulated in vitro in response to LPS stimulation
Walton et al., Arterioscler Thromb Vasc Biol 2003 : Supporting an important role for caveolae in LPS action, overexpression of caveolin-1 enhanced LPS induced IL-8 synthesis
Lei et al., Infect Immun 2005 : Interestingly, polymyxin B ( 5 microg/ml ) and RsDPLA show only a limited capacity to inhibit LPS induced caveolin-1 expression ... These findings suggest that expression of caveolin-1 in response to LPS may only partially be dependent upon lipid A. Recombinant tumor necrosis factor alpha marginally induces caveolin-1, suggesting that the ability of LPS to regulate caveolin-1 is not mediated primarily through an autocrine/paracrine mechanism involving this cytokine ... Gamma interferon treatment inhibits the induction of caveolin-1 by LPS in macrophages