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IL8 — NFKBIA

Text-mined interactions from Literome

Alpert et al., J Biol Chem 1999 : In addition, sorbitol and H ( 2 ) O ( 2 ) blocked TNF induced but not interleukin-1 induced IkappaBalpha phosphorylation, whereas arsenite inhibited IkappaBalpha phosphorylation induced by TNF and interleukin-1
Griesenbach et al., Gene Ther 2000 (Cystic Fibrosis) : Liposome mediated transfection of IkappaBalpha did not reduce IL-8 secretion, probably due to low transfection efficiency ( approximately 5 % of cells )
Mazor et al., Cytokine 2000 : Stabilization of cytoplasmic I-kappaBalpha leads to inhibition of NF-kappaB nuclear translocation and of subsequent IL-8 promoter activation
Zoja et al., Kidney Int 2002 (Hemolytic-Uremic Syndrome) : Adenovirus mediated gene transfer of IkappaBalpha down-regulated IL-8 and MCP-1 mRNA and also inhibited the adhesion and transmigration of leukocytes in Stx treated HUVEC
Pei et al., Cytokine 2002 : Overexpression of IkappaBalpha inhibited 1-NP induced transcription of IL-8
Xu et al., Biochem Biophys Res Commun 2004 : TWEAK induced phosphorylation of IkappaBalpha and BAY11-7082, a selective inhibitor of IkappaBalpha phosphorylation, inhibited the TWEAK induced IL-8 and GM-CSF production by BEAS2B cells
Cowburn et al., Eur J Immunol 2004 : Inhibition of I kappa B-alpha phosphorylation, PI3-kinase or ERK1/2 activation blocked IL-8 release by both cytokines
Soloff et al., Mol Hum Reprod 2004 : We were unable to detect any significant differences between primary and immortalized cells in signal pathways such as epidermal growth factor stimulated epidermal growth factor receptor phosphorylation, insulin stimulated Akt phosphorylation, oxytocin and lysophosphatidic acid stimulated extracellular signal regulated kinase 1 and 2 phosphorylation, myosin light chain phosphorylation, and interleukin-1 induction of IkappaBalpha degradation
Manna et al., J Biol Chem 2005 : IL-8 also induces IkappaBalpha phosphorylation followed by degradation and p65 translocation
Catley et al., Br J Pharmacol 2005 (Asthma) : Similarly, IKK beta ( KA ) and I kappa B alpha delta N overexpression also inhibited IL-1beta- and TNF alpha dependent increases in ICAM-1, IL-8 and GM-CSF in addition to IL-1beta mediated increases in cyclooxygenase-2 expression, whereas IKK alpha ( KM ) overexpression had little effect on these outputs
Wong et al., Am J Respir Cell Mol Biol 2005 : IL-25 could also activate the JNK, p38 MAPK, and NF-kappaB activities of eosinophils, while inhibitor of IkappaB-alpha phosphorylation ( BAY11-7082 ), JNK ( SP600125 ), and p38 MAPK ( SB203580 ) could suppress the release of IL-8 , MIP-1alpha, MCP-1, and IL-6
Fritz et al., J Biomed Mater Res A 2006 (Prosthesis Failure) : Inhibition studies with N-acetyl-L-cysteine (Nac) and MG-132 suggest that titanium particle activation of NF-kappaB activity and IL-8 chemokine expression involves oxidant signaling and IkappaBalpha-proteasomal degradation
Hirata et al., J Immunol 2006 : In human epithelial cells, H. pylori induced IkappaBalpha phosphorylation and IL-8 production were severely inhibited by siRNAs directed against TAK1, TRAF6, and MyD88
Thompson et al., Am J Respir Cell Mol Biol 2006 (Asthma) : Overexpression of dominant negative IkappaBalpha inhibited the IL-8 transactivation induced by LTD ( 4 )
Newton et al., J Pharmacol Exp Ther 2007 (Pulmonary Disease, Chronic Obstructive) : In A549 cells, interleukin (IL)-1beta and tumor necrosis factor (TNF) alpha increased phosphorylation of IkappaBalpha , and this was followed by loss of IkappaBalpha, induction of NF-kappaB DNA binding, and the induction of NF-kappaB dependent transcription
Ning et al., Respirology 2007 (Respiratory Distress Syndrome, Adult) : Cyclic mechanical stretch can activate Rel A translocation and IkappaBalpha degradation, thus inducing the secretion of IL-8 in alveolar epithelial type II cells
Thompson et al., J Biol Chem 2008 (Inflammation) : Overexpression of dominant negative IkappaBalpha prevented the IL-8 transactivation induced by LTC ( 4 )
Hisatsune et al., J Immunol 2008 : Inhibitors of p38 MAPK ( SB203580 ), ERK1/2 ( PD98059 ), IkappaBalpha ( ( E ) -3- ( 4-methylphenylsulfonyl ) -2-propenenitrile ), Ca ( 2+ ) entry ( SKF96365 ), and intracellular Ca ( 2+ ) channels ( dantrolene ) blocked VacA induced IL-8 production
Boost et al., Int J Mol Med 2009 : We, therefore, aimed to investigate the effects of the volatile anesthetics sevoflurane and isoflurane on NF-kappaB/IkappaBalpha dependent intracellular signal transduction in human monocytic THP-1 cells induced by tumor necrosis factor-alpha (TNF-alpha) and production of interleukin-8 (IL-8) and downstream heme oxygenase-1 (HO-1)
Sierra et al., Microb Pathog 2010 (Gram-Negative Bacterial Infections) : Further, AexU prevented phosphorylation of c-Jun, JNK and IkappaBalpha and inhibited IL-6 and IL-8 secretion from HeLa cells
Lee et al., J Biol Chem 1998 (Ovarian Neoplasms) : Paclitaxel induced IL-8 promoter activation was inhibited by dominant-inhibitory mutants of JNK, p38, and the super-repressor form of IkappaBalpha , but not by dominant-inhibitory forms of ERK1